{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:12:19Z","timestamp":1793041939026,"version":"4.5.0"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["\"Ricerca Corrente\""],"award-info":[{"award-number":["\"Ricerca Corrente\""]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Gallbladder cancer (GBC) is a highly lethal and often overlooked malignancy increasingly affecting young adults. This study quantified the global proportion of GBC cases attributable to 10 key modifiable risk factors, employing Monte Carlo simulations and estimates from field\u2010wide systematic review and meta\u2010analysis. Approximately three\u2010quarters of global GBC cases are attributable to key modifiable factors (74.6%; 95% uncertainty interval, 63.7\u201383.7), with a slightly higher share observed in females. Central obesity (29.7%; 8.7\u201349.5), gallstones (27.9%; 16.8\u201340.7), and physical inactivity (20.5%; 7.4\u201334.1) were identified as the leading contributors. Most GBC cases are preventable, with a large share linked to metabolic health conditions.<\/jats:p>","DOI":"10.1111\/apt.18486","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T08:20:51Z","timestamp":1736151651000},"page":"886-890","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Global Burden of Gallbladder Cancer Attributable to Modifiable Risk Factors"],"prefix":"10.1111","volume":"61","author":[{"given":"Daniele","family":"Piovani","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Pieve Emanuele, Milan Italy"},{"name":"IRCCS Humanitas Research Hospital  Rozzano, Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios K.","family":"Nikolopoulos","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Statistics, Epidemiology and Public Health, Medical School University of Cyprus  Nicosia Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0740-1363","authenticated-orcid":false,"given":"Gisella","family":"Figlioli","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Pieve Emanuele, Milan Italy"},{"name":"IRCCS Humanitas Research Hospital  Rozzano, Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3695-0759","authenticated-orcid":false,"given":"Andreas G.","family":"Tsantes","sequence":"additional","affiliation":[{"name":"Laboratory of Haematology and Blood Bank Unit \"Attiko\" Hospital, School of Medicine, National and Kapodistrian University of Athens  Athens Greece"},{"name":"Microbiology Department \"Saint Savvas\" Oncology Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanos","family":"Bonovas","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Pieve Emanuele, Milan Italy"},{"name":"IRCCS Humanitas Research Hospital  Rozzano, Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00153-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(18)30267-6"},{"issue":"24","key":"e_1_2_9_4_1","first-page":"866","article-title":"Environmental Risk Factors for Gallbladder Cancer: Field\u2010Wide Systematic Review and Meta\u2010Analysis","volume":"1542","author":"Piovani D.","year":"2024","journal-title":"Clinical Gastroenterology and Hepatology"},{"key":"e_1_2_9_5_1","first-page":"531","article-title":"The Occurrence of Lung Cancer in Man","volume":"9","author":"Levin M. 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