{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T19:28:17Z","timestamp":1785526097502,"version":"3.56.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The impact of prophylactic medication following ileocecal resection (ICR) for Crohn's disease (CD) merits further elucidation. Prophylactic medication following ileocecal resection (ICR) is recommended in patients with Crohn\u2019s disease (CD), particularly in patients at increased risk of recurrence, but the impact on long\u2010term outcomes needs to be further elucidated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the effect of postoperative prophylactic medication on long\u2010term prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study was performed in patients with CD who underwent primary ICR between 2000\u20102020 in the Netherlands. Patients were divided into two groups: postoperative prophylactic medication [&lt;\u200912\u2009weeks following ICR] versus no postoperative prophylactic medication. Outcomes were surgical recurrence [re\u2010resection for CD], severe endoscopic recurrence [modified Rutgeerts score (mRS) \u2265\u2009i3] and endoscopic or radiologic recurrence [mRS \u2265\u2009i2b or radiologic recurrence]. Inverse probability of treatment weighting [IPTW] method was used to adjust for confounding and selection bias. Survival and association between postoperative prophylactic medication and outcomes were assessed with Kaplan\u2010Meier analyses and Cox proportional hazard models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>807 patients underwent ICR (median follow\u2010up 5.0 years); 36% received postoperative prophylactic medication. Surgical, severe endoscopic and endoscopic or radiologic recurrence rates were significantly lower in those who received prophylactic medication (<jats:italic>p<\/jats:italic>\u2009=\u20090.01; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). IPTW analysis showed a lower risk of severe endoscopic and endoscopic or radiologic recurrence in patients treated with postoperative prophylactic medication (aOR 0.64; 95% CI 0.43\u20130.97; aOR 0.65; 95% CI 0.47\u20130.91), which also was identified as a protective factor for severe endoscopic (aHR 0.5; 95% CI 0.4\u20130.6) and endoscopic or radiologic recurrence (aHR 0.6, 95% CI 0.5\u20130.7) in multivariable analysis after correction for confounding factors. A comparable protective effect of postoperative prophylactic medication was sustained in patients who underwent ileocolonoscopy &lt;1 year postoperatively and who underwent surgery on or after 2010.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Prophylactic medication following primary ICR significantly reduces long\u2010term recurrence rates in CD and was identified as a protective factor for severe endoscopic and endoscopic or radiologic recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.18496","type":"journal-article","created":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T04:54:31Z","timestamp":1737780871000},"page":"1019-1031","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Impact of Postoperative Prophylactic Medication on Long\u2010Term Surgical, Severe Endoscopic and Endoscopic or Radiologic Recurrence Following Primary Ileocecal Resection in Patients With Crohn's Disease"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0618-3018","authenticated-orcid":false,"given":"Sebastiaan","family":"ten Bokkel Huinink","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Erasmus University Medical Center Rotterdam  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8515-425X","authenticated-orcid":false,"given":"Michiel T. J.","family":"Bak","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Erasmus University Medical Center Rotterdam  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelien M. J.","family":"Beelen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Erasmus University Medical Center Rotterdam  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole S.","family":"Erler","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Erasmus Medical Center  Rotterdam the Netherlands"},{"name":"Department of Epidemiology Erasmus Medical Center  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Silverberg","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine Mount Sinai Hospital, University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2012-7522","authenticated-orcid":false,"given":"Matthieu","family":"Allez","sequence":"additional","affiliation":[{"name":"Gastroenterology Department H\u00f4pital Saint\u2010Louis\u2010APHP, Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5314-4452","authenticated-orcid":false,"given":"Frank","family":"Hoentjen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Radboud Medical Center  Nijmegen the Netherlands"},{"name":"Division of Gastroenterology, Department of Medicine University of Alberta  Edmonton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander G. L.","family":"Bodelier","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Amphia Hospital  Breda the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Dijkstra","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Medical Center Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marielle","family":"Romberg\u2010Camps","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Zuyderland Medical Center  Sittard\u2010Geleen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanne K. H.","family":"de Boer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute Amsterdam University Medical Centre, Vrije Universiteit Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurents P. S.","family":"Stassen","sequence":"additional","affiliation":[{"name":"Department of Surgery Maastricht Medical Center  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea E.","family":"van der Meulen \u2013 de Jong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Leiden Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel L.","family":"West","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Sint Franciscus Gasthuis &amp; Vlietland  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Janneke","family":"van der Woude","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Erasmus University Medical Center Rotterdam  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oddeke","family":"van Ruler","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Erasmus University Medical Center Rotterdam  Rotterdam the Netherlands"},{"name":"Department of Surgery IJsselland Hospital  Capelle aan den IJssel the Netherlands"},{"name":"Department of Surgery Erasmus Medical Center  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarie C.","family":"de Vries","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Erasmus University Medical Center Rotterdam  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Dutch Initiative on Crohn and Colitis (ICC)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.10.039"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/AS9.0000000000000397"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjw169"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.10.038"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjx051"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.194159"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.10.021"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.13047"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8618574"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izac158"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.12.035"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.072"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2022.09.004"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2022.07.013"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjac100"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjae011"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002509"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.03.064"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izab316"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjad053"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.6607"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.18040"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318484"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61908-5"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjac128"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjad054"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.06.019"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60304-9"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904492"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-008-0542-9"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14944"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003531"},{"key":"e_1_2_11_34_1","article-title":"Combined Clinical and Histopathological Risk Stratification for Prediction of (Severe) Endoscopic Postoperative Recurrence in Patients With Crohn's Disease After Ileocolic Resection","author":"Bak M. 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