{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:16:09Z","timestamp":1789755369466,"version":"4.0.1"},"reference-count":57,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T00:00:00Z","timestamp":1737158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Novel colorectal cancer endoscopic surveillance techniques for inflammatory bowel disease (IBD) have recently been developed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Compare the efficacy of currently available techniques for dysplasia detection in colonic IBD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a systematic literature search from inception to March 2024 for randomized controlled trials (RCTs) or prospective cohort studies enrolling adults with IBD and having surveillance colonoscopy for dysplasia screening. Primary outcome was the number of dysplastic lesions (per\u2010lesion analysis). Secondary outcome was the number of patients with dysplasia (per\u2010patient analysis). We assessed endpoints using the frequentist NMA random effect model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 25 studies (22 RCTs). 4837 patients met eligibility criteria (850 total dysplastic lesions; 105 with advanced dysplasia). Nine different screening techniques were studied. In per\u2010lesion analysis, dye\u2010based chromoendoscopy (DCE) ranked the highest (83%) per SUCRA ranking. DCE was superior to HD\u2010WLE (OR, 1.78; 95% CI, 1.06\u20133.00). There were no significant differences between NBI and DCE, HD\u2010WLE with SR or CEM in head\u2010to\u2010head comparisons. In a sub\u2010analysis confined to ulcerative colitis (UC), DCE ranked highest (98%) with per\u2010lesion analysis, and was superior to NBI (OR, 1.69; 95% CI, 1.03\u20132.77).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HD\u2010WLE\u2010SR, DCE and CEM demonstrated superiority over other techniques for detection of dysplasia in colonic IBD. DCE was superior for dysplasia detection in colonic IBD. DCE was superior to HD\u2010WLE in colonic IBD. DCE was the best technique in UC. Further studies to compare HD\u2010WLE\u2010SR and NBI with DCE are warranted to ascertain performance equivalency and define the optimal surveillance technique.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.18500","type":"journal-article","created":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T09:19:41Z","timestamp":1737191981000},"page":"938-949","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Network Meta\u2010Analysis: Comparison of Endoscopic Dysplasia Detection Technologies in Inflammatory Bowel Disease"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2084-3956","authenticated-orcid":false,"given":"Mohammad","family":"Shehab","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Mubarak Alkabeer University Hospital, Kuwait University  Kuwait City Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Al\u2010Hindawi","sequence":"additional","affiliation":[{"name":"School of Medicine, Royal College of Surgeons in Ireland \u2010 Medical University of Bahrain  Busaiteen Bahrain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatema","family":"Alrashed","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Faculty of Pharmacy Kuwait University  Jabriya Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Murthy","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raf","family":"Bisschops","sequence":"additional","affiliation":[{"name":"University Hospitals Leuven, TARGID, KU Leven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5314-4452","authenticated-orcid":false,"given":"Frank","family":"Hoentjen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Barkun","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine McGill University Health Center  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddharth","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talat","family":"Bessissow","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine McGill University Health Center  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000368447"},{"issue":"9","key":"e_1_2_11_3_1","first-page":"1323","article-title":"Ulcerative Colitis: Diagnosis and Treatment","volume":"76","author":"Langan R. 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