{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,13]],"date-time":"2025-04-13T04:08:13Z","timestamp":1744517293651,"version":"3.40.4"},"reference-count":10,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Proton pump inhibitors (PPIs) decrease pancreatic exocrine secretions. There has been interest in the impact of their short\u2010term in\u2010hospital administration on acute pancreatitis (AP) outcomes. It is unknown whether long\u2010term use affects AP outcomes. We investigated the association between chronic PPI use and short\u2010term AP outcomes. We included all (2308) patients admitted with a primary diagnosis of AP (625 on chronic PPI use) between January 2008 and June 2021 and evaluated any association between chronic PPI use and 30\u2010day all\u2010cause mortality by univariate logistic regression. Compared to non\u2010users, patients on chronic PPIs were older (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and had a higher Charlson Comorbidity Index score (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Mortality rates at 30\u2009days were 1.6% in chronic PPI users and 4.4% in non\u2010users (OR 0.35; 95% CI, 0.17\u20130.66; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.002). [Correction added on 18 February 2025, after first online publication: Mortality rates at 30 days in chronic PPI users and non\u2010users were updated in this version.]<\/jats:p>","DOI":"10.1111\/apt.18523","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T08:53:40Z","timestamp":1738313620000},"page":"1387-1390","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chronic Use of Proton Pump Inhibitors Is Associated With Reduced 30\u2010Day Mortality From Acute Pancreatitis"],"prefix":"10.1111","volume":"61","author":[{"given":"Maya","family":"Fischman","sequence":"first","affiliation":[{"name":"Department of Military Medicine, Faculty of Medicine Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adi","family":"Elias","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of California  California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Rambam Health Care Campus  Haifa Israel"},{"name":"Rappaport Faculty of Medicine Technion, Israel Institute of Technology  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaron","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Military Medicine, Faculty of Medicine Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaher S.","family":"Azzam","sequence":"additional","affiliation":[{"name":"Rappaport Faculty of Medicine Technion, Israel Institute of Technology  Haifa Israel"},{"name":"Division of Medicine Rambam Health Care Campus  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0714-5686","authenticated-orcid":false,"given":"Itai","family":"Ghersin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Rambam Health Care Campus  Haifa Israel"},{"name":"Rappaport Faculty of Medicine Technion, Israel Institute of Technology  Haifa Israel"},{"name":"Inflammatory Bowel Disease Unit St. Mark's Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2010.09.008"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0126432"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000037694"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.772975"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-29939-5"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2015.07.006"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.25.12.1340"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm18001"},{"issue":"5","key":"e_1_2_7_11_1","first-page":"310","article-title":"Epidemiology of Acute Pancreatitis in Southern Israel: A Retrospective Study","volume":"22","author":"Polishchuk I.","year":"2020","journal-title":"Israel Medical Association Journal"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.18523","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T07:11:29Z","timestamp":1744441889000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.18523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,31]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/apt.18523"],"URL":"https:\/\/doi.org\/10.1111\/apt.18523","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"type":"print","value":"0269-2813"},{"type":"electronic","value":"1365-2036"}],"subject":[],"published":{"date-parts":[[2025,1,31]]},"assertion":[{"value":"2024-10-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}