{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:40:08Z","timestamp":1791906008563,"version":"4.3.4"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101RAs) have shown promise in reducing alcohol consumption, but their impact on clinical outcomes in patients with alcohol use disorder (AUD) remains unclear. We investigated the association between GLP\u20101RAs and the development and progression of alcohol\u2010related liver disease (ArLD) in patients with AUD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the TriNetX Research Network, we conducted two retrospective cohort studies comparing GLP\u20101RAs versus dipeptidyl peptidase\u20104 inhibitors (DPP\u20104is) in patients with type 2 diabetes. The first cohort included patients with AUD but without ArLD (<jats:italic>n<\/jats:italic>\u2009=\u20097132 after propensity score matching), while the second comprised patients with established ArLD (<jats:italic>n<\/jats:italic>\u2009=\u20091896 after matching). Primary outcomes were incident ArLD in the AUD cohort and hepatic decompensation in the ArLD cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the AUD cohort (median follow\u2010up: 63.2\u2009months), GLP\u20101RA users showed significantly lower risks of developing ArLD compared to DPP\u20104i users (incidence rate: 6.0 vs. 8.7 per 1000 person\u2010years; HR: 0.62, 95% CI: 0.44\u20130.87, <jats:italic>p<\/jats:italic>\u2009=\u20090.006). GLP\u20101RAs were also associated with reduced risks of all\u2010cause mortality (HR: 0.53, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In the ArLD cohort (median follow\u2010up: 28.2\u2009months), GLP\u20101RA users demonstrated lower risks of hepatic decompensation (incidence rate: 39.5 vs. 51.4 per 1000 person\u2010years; HR: 0.66, 95% CI: 0.51\u20130.85, <jats:italic>p<\/jats:italic>\u2009=\u20090.001) and all\u2010cause mortality (HR: 0.53, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) compared to DPP\u20104i users.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>GLP\u20101RAs were associated with reduced risks of developing and progressing ArLD in patients with AUD, suggesting potential therapeutic benefits in this population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.70007","type":"journal-article","created":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T06:18:47Z","timestamp":1738390727000},"page":"1343-1356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Impact of <scp>GLP<\/scp>\u20101 Receptor Agonists on Alcohol\u2010Related Liver Disease Development and Progression in Alcohol Use Disorder"],"prefix":"10.1111","volume":"61","author":[{"given":"Chia\u2010Chih","family":"Kuo","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Chi Mei Medical Center  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Hsien","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Chi Mei Medical Center  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min\u2010Hsiang","family":"Chuang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chi Mei Medical Center  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po\u2010Yu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chi Mei Medical Center  Tainan 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Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00122-1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2024.06.006"},{"key":"e_1_2_9_4_1","unstructured":"Substance Abuse and Mental Health Services Administration \u201cKey Substance Use and Mental Health Indicators in the United States: Results from the 2022 National Survey on Drug Use and Health \u201daccessed October 12 2024 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