{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:31:01Z","timestamp":1790775061798,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:00:00Z","timestamp":1739232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe","doi-asserted-by":"publisher","award":["#70115730"],"award-info":[{"award-number":["#70115730"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5UL1TR001442"],"award-info":[{"award-number":["5UL1TR001442"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01DK061734"],"award-info":[{"award-number":["U01DK061734"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01DK130190"],"award-info":[{"award-number":["U01DK130190"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The recent consensus statement redefined steatotic liver diseases. Metabolic dysfunction\u2010associated steatotic liver disease (MASLD) and metabolic dysfunction and alcohol\u2010related liver disease (MetALD) now represent distinct disease entities. However, biomarkers that differentiate MASLD and MetALD remain largely unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To identify lipidomic biomarkers with discriminatory potential for distinguishing MetALD from MASLD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using the UK Biobank dataset, 40,534 people with available MRI liver scans were analysed. A total of, 11,217 cases with a proton density fat fraction (PDFF) \u2265\u20095% were identified as having steatotic liver disease. Among these, lipidomic profiles were obtained for 5539 MASLD and 462 MetALD cases. A total of, 250 plasma lipidomic and metabolomic parameters were analysed. Mendelian randomisation (MR) analysis was used to confirm the association between alcohol consumption and the lipidomic biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>When comparing the top 30 differentially expressed lipidomic biomarkers predicting MetALD compared to MASLD, the majority were related to HDL and were significantly overrepresented at both analysed time points. The top five metabolites were: acetoacetate, 3\u2010hydroxybutyrate, phospholipids in Large HDL, concentration of large HDL particles, free cholesterol in large HDL. The sensitivity analysis comparing alcohol\u2010related liver disease to MASLD revealed similar associations, suggesting that the HDL signature is stable over time. Additionally, MR analysis further confirmed that alcohol consumption was associated with increased levels of HDL\u2010related metabolites.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings indicate that HDL\u2010centric lipidomic markers, particularly those within the larger and medium HDL subfraction, may differentiate MetALD from MASLD. Further longitudinal and experimental studies are warranted to validate these findings and assess their clinical implications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70012","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T02:24:02Z","timestamp":1739327042000},"page":"1357-1371","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The Lipidomic Profile Discriminates Between\n                    <scp>MASLD<\/scp>\n                    and\n                    <scp>MetALD<\/scp>"],"prefix":"10.1111","volume":"61","author":[{"given":"Kai Markus","family":"Schneider","sequence":"first","affiliation":[{"name":"Department of Internal Medicine III, Gastroenterology, Metabolic Diseases and Intensive Care University Hospital RWTH Aachen  Aachen Germany"},{"name":"Department of Medicine I, Deptartment of Gastroenterology and Hepatology, Faculty of Medicine and University Hospital Carl Gustav Carus TUD Dresden University of Technology  Dresden Germany"},{"name":"Center for Regenerative Therapies Dresden (CRTD) Technische Universit\u00e4t (TU) Dresden  Dresden Germany"},{"name":"Else Kroener Fresenius Center for Digital Health, Faculty of Medicine and University Hospital Carl Gustav Carus TUD Dresden University of Technology  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Gastroenterology, Metabolic Diseases and Intensive Care University Hospital RWTH Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen Ye Rim","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Gastroenterology, Metabolic Diseases and Intensive Care University Hospital RWTH Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanlan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hepatology &amp; Gastroenterology, Campus Virchow\u2010Klinikum and Campus Charit\u00e9 Mitte Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yazhou","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Gastroenterology, Metabolic Diseases and Intensive Care University Hospital RWTH Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongpeng","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Gastroenterology, Metabolic Diseases and Intensive Care University Hospital RWTH Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Raptis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Gastroenterology, Metabolic Diseases and Intensive Care University Hospital RWTH Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1870-4586","authenticated-orcid":false,"given":"Kate Townsend","family":"Creasy","sequence":"additional","affiliation":[{"name":"Department of Biobehavioral Health Sciences, School of Nursing University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Clusmann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Gastroenterology, Metabolic Diseases and Intensive Care University Hospital RWTH Aachen  Aachen Germany"},{"name":"Else Kroener Fresenius Center for Digital Health, Faculty of Medicine and University Hospital Carl Gustav Carus TUD Dresden University of Technology  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"van Haag","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Gastroenterology, Metabolic Diseases and Intensive Care University Hospital RWTH Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul\u2010Henry","family":"Koop","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Gastroenterology, Metabolic Diseases and Intensive Care University Hospital RWTH Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Guillot","sequence":"additional","affiliation":[{"name":"Department of Hepatology &amp; 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