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The global prevalence of metabolic diseases, including diabetes, chronic liver disease, cardiometabolic disease and kidney disease, has surged in recent decades, contributing significantly to population mortality. Metabolic dysfunction\u2010associated steatotic liver disease (MASLD), formerly known as non\u2010alcoholic fatty liver disease, is a leading cause of liver disease worldwide. MASLD poses a significant global health challenge with its rising prevalence, placing a substantial burden on healthcare systems, impacts patient well\u2010being and incurs significant economic costs. Addressing MASLD requires a comprehensive understanding of its interconnected factors, including its prevalence, healthcare burden and economic implications. Lack of awareness, imprecise non\u2010invasive diagnostic methods and ineffective preventive interventions are core components of the MASLD\u2010related problem.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim of this article was to summarise the global burden of MASLD from the payer's perspective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We carried out a review of the global comprehensive burden of MASLD. These topics led to discussions and insights by an expert panel during the 7th Metabolic Continuum Roundtable meeting, which took place in November 2023. This meeting focused on the burden, patient\u2010reported outcomes and health economics, from payor and societal perspectives, and aimed to identify opportunities for improving patient care, optimise resource allocation and mitigate the overall impact on individuals and society related to MASLD. During the roundtable, an emphasis emerged on the need for greater awareness and strategic deployment of diagnostic, therapeutic and preventative measures to address MASLD effectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The global burden of MASLD is high and growing. Prioritising the prevention of metabolic dysregulation and timely therapeutic interventions can yield a holistic strategy to combat MASLD, its progression and potentially lower disease costs.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      NCT06309992\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70020","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T01:10:52Z","timestamp":1739927452000},"page":"1467-1478","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Addressing the High and Rising Global Burden of Metabolic Dysfunction\u2010Associated Steatotic Liver Disease (\n                    <scp>MASLD<\/scp>\n                    ) and Metabolic Dysfunction\u2010Associated Steatohepatitis (\n                    <scp>MASH<\/scp>\n                    ): From the Growing Prevalence to Payors' Perspective"],"prefix":"10.1111","volume":"61","author":[{"given":"Zobair M.","family":"Younossi","sequence":"first","affiliation":[{"name":"Beatty Liver and Obesity Research Program Inova Health System  Falls Church Virginia USA"},{"name":"The Global NASH Council  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Homie","family":"Razavi","sequence":"additional","affiliation":[{"name":"Center for Disease Analysis Foundation  Lafayette Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sherman","sequence":"additional","affiliation":[{"name":"RA Capital Management, L.P.  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