{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T21:11:39Z","timestamp":1789161099404,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["114\u2010S0108"],"award-info":[{"award-number":["114\u2010S0108"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Data regarding the risk of incident type 2 diabetes (T2D) and prediabetes among patients with hepatitis C virus (HCV) achieving direct\u2010acting antivirals (DAAs)\u2010induced sustained virologic response (SVR<jats:sub>12<\/jats:sub>) remains limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1079 patients, including 589 with normoglycemia and 490 with prediabetes, who underwent biannual fasting glucose and glycosylated haemoglobin (HbA1c) assessment for a median post\u2010SVR<jats:sub>12<\/jats:sub> follow\u2010up of 5.5\u2009years, were enrolled. We reported the crude (cIRs) and age\u2010standardised incidence rates (ASIRs) of T2D and prediabetes. Factors associated with incident T2D and prediabetes were assessed using the Cox proportional hazards models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cIRs of T2D and prediabetes were 1.18 and 8.99 per 100 person\u2010years of follow\u2010up (PYFU), respectively. Additionally, the ASIRs of T2D and prediabetes were 1.09 (95% CI: 0.76\u20131.53) and 8.47 (95% CI: 7.23\u20139.90) per 100 PYFU. Prediabetes (adjusted hazard ratio [aHR]: 4.71; 95% confidence interval (CI): 2.55\u20138.70, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), body mass index (BMI) per kg\/m<jats:sup>2<\/jats:sup> increase (aHR: 1.17; 95% CI: 1.09\u20131.26, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and liver stiffness measurement (LSM) per kPa increase (aHR: 1.05; 95% CI: 1.02\u20131.09, <jats:italic>p<\/jats:italic>\u2009=\u20090.001) were associated with a higher risk of incident T2D. Age per year increase (aHR: 1.02; 95% CI: 1.01\u20131.03, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) was associated with a higher risk of incident prediabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The incidence rates of T2D and prediabetes remain substantial among patients after HCV eradication. Lifestyle modification, drug therapy and regular monitoring of glycemic status are crucial for patients at risk of developing T2D and prediabetes following HCV clearance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.70029","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:05:30Z","timestamp":1740135930000},"page":"1508-1518","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Risk of Incident Type 2 Diabetes and Prediabetes in Patients With Direct Acting Antiviral\u2010Induced Cure of Hepatitis C Virus Infection"],"prefix":"10.1111","volume":"61","author":[{"given":"Yu\u2010Ping","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Biomedical Park Hospital  Hsin\u2010Chu 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National Chung Hsing University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Lueng","family":"Shih","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Tri\u2010Service General Hospital, National Defense Medical Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9030-6086","authenticated-orcid":false,"given":"Cheng\u2010Yuan","family":"Peng","sequence":"additional","affiliation":[{"name":"Center for Digestive Medicine, Department of Internal Medicine China Medical University Hospital  Taichung Taiwan"},{"name":"School of Medicine China Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu\u2010Jen","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Fu Jen Catholic University 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