{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T11:19:19Z","timestamp":1781608759898,"version":"3.54.5"},"reference-count":53,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Updated data on the survival of patients with cirrhosis are limited, especially for subgroups by specific liver disease aetiology. To inform practice, future modelling studies, and public health planning, our study aimed to provide updated and granular data on survival outcomes of patients with cirrhosis stratified by liver disease aetiology. We also assessed their changes over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analysed 8726 consecutive adult patients with cirrhosis who presented at Stanford university medical center during 1\/2005\u20131\/2022.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>8726 Patients had the following etiologies: hepatitis C virus (HCV) (28.1%), hepatitis B virus (HBV) (4.8%), alcohol\u2010associated (ALD, 33.3%), metabolic\u2010associated steatotic liver disease (MASLD) (9.5%), autoimmune (9.6%), cryptogenic (8.2%) and other etiologies (6.5%). Patients with cryptogenic cirrhosis had the lowest overall 5\u2010, 10\u2010, and 15\u2010year cumulative survival (57.5%, 34.3% and 21.4%), as well as for liver and nonliver\u2010related death, followed by ALD, MASLD, HCV, and autoimmune, while HBV patients had the best survival (86.0%, 70.1% and 65.1%), respectively. On multivariable Cox regression, cryptogenic cirrhosis (vs. HBV) was associated with the highest risk of all\u2010cause death (aHR: 2.24, 95% CI 1.67\u20133.00), followed by MASLD and ALD (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Post\u20102010 time was associated with a 33% lower risk of all\u2010cause death (<jats:italic>p<\/jats:italic>\u2009=\u20090.0011); While in the post\u20102010 period, MASLD (vs. HBV) was associated with the highest risk of all\u2010cause death (aHR: 1.92, 95% CI 1.32\u20132.80, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) followed by cryptogenic and ALD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Survival outcomes in patients with cirrhosis varied by aetiology and have changed over time, which should be taken into account for future practice guidelines and modelling studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.70059","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T09:42:44Z","timestamp":1741772564000},"page":"1622-1634","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Differential Characteristics and Survival Outcomes of Patients With Cirrhosis According to Underlying Liver Aetiology"],"prefix":"10.1111","volume":"61","author":[{"given":"Yu","family":"Shi","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Stanford University Medical Center  Palo Alto California USA"},{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Chien","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Stanford University Medical Center  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Fong","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Stanford University Medical Center  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vy H.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Stanford University Medical Center  Palo Alto California USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surya Teja","family":"Gudapati","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Stanford University Medical Center  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Chau","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Stanford University Medical Center  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Tran","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Stanford University Medical Center  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Henry","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Stanford University Medical Center  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramsey","family":"Cheung","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Stanford University Medical Center  Palo Alto California USA"},{"name":"Division of Gastroenterology and Hepatology Veterans Affairs Palo Alto Health Care System  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changqing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cirrhosis, Institute of Liver Disease, Shuguang Hospital Shanghai University of T.C.M.  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