{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T21:00:53Z","timestamp":1793912453941,"version":"4.8.0"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Real\u2010world effectiveness and safety of upadacitinib in patients with Crohn's disease (CD) remain unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study aimed to evaluate the effectiveness and safety of upadacitinib in a real\u2010world cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From September 2022 to June 2024, all consecutive patients with refractory luminal CD treated with once daily upadacitinib 45\u2009mg in 29 French GETAID centres were retrospectively included. The primary outcome was steroid\u2010free clinical remission (SFCR) at week 12, defined as a Harvey\u2013Bradshaw Index (HBI) of &lt;\u20094. Clinical response (decrease of \u2265\u20093 points in HBI and\/or HBI &lt;\u20094), clinical remission, biomarker remission, endoscopic and\/or radiologic response and safety were also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 223 patients included, all were previously exposed to at least one biologic (median 4, IQR [3, 4]) and 119 (53.8%) had prior intestinal resection. At week 12, SFCR was achieved in 107\/197 (54%), clinical response in 129\/197 (65%) and clinical remission in 111\/197 (56%). A total of, 90 out of 173 (52%) achieved biomarker remission. Endoscopic and\/or radiologic response was observed in 18\/38 (47%) patients. Clinical response of extraintestinal manifestations was observed in 37\/47 (79%) patients and clinical remission in 29\/47 (62%). A total of, 65 adverse events (AEs) occurred in 58 patients (26%), including 17 serious AEs, 16 disease exacerbation and one case of colonic EBV\u2010associated lymphoproliferative disorder. Acne was reported in 24\/223 (11%) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this real\u2010world cohort of highly refractory CD patients, upadacitinib induction resulted in a clinical response in about two\u2010thirds of patients and in SFCR in half of the patients, with an acceptable safety profile.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.70073","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T21:26:25Z","timestamp":1741382785000},"page":"1662-1670","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Effectiveness and Safety of Upadacitinib Induction Therapy for 223 Patients With Crohn's Disease: A <scp>GETAID<\/scp> Multicentre Cohort Study"],"prefix":"10.1111","volume":"61","author":[{"given":"Nicolas","family":"Richard","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Univ Rouen Normandie, INSERM, ADEN UMR1073, \u201cNutrition, Inflammation and Microbiota\u2010Gut\u2010Brain Axis\u201d, CHU Rouen  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Amiot","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hopitaux Universitaires Bic\u00eatre, AP\u2010HP, Universit\u00e9 Paris Saclay, INSERM CESP  Le Kremlin Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Seksik","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology CRSA, Sorbonne Universit\u00e9, INSERM, APHP, H\u00f4pital Saint\u2010Antoine  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4618-7942","authenticated-orcid":false,"given":"Romain","family":"Altwegg","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology CHU of Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4753-6676","authenticated-orcid":false,"given":"David","family":"Laharie","sequence":"additional","affiliation":[{"name":"CHU de Bordeaux, Centre Medico\u2010Chirurgical Magellan, H\u00f4pital Haut\u2010L\u00e9v\u00eaque, Gastroenterology Department Universit\u00e9 de Bordeaux; INSERM CIC 1401  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9845-6572","authenticated-orcid":false,"given":"Lucine","family":"Vuitton","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology UMR 1098, University of Franche\u2010Comt\u00e9  Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Nachury","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, U1286, INFINITE, Institute for Translational Research in Inflammation  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7444-5905","authenticated-orcid":false,"given":"Guillaume","family":"Bouguen","sequence":"additional","affiliation":[{"name":"CHU Rennes, Univ Rennes, INSERM, CIC1414, Institut NUMECAN (Nutrition Metabolism and Cancer)  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Nancey","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Lyon\u2010Sud Hospital, CHU of Lyon, and INSERM U1111, CIRI  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrielle","family":"Gilletta","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Pancreatology CHU of Toulouse RANGUEIL  Toulouse 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