{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:16:51Z","timestamp":1790878611175,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Linaprazan glurate, a potassium\u2010competitive acid blocker, is in development for the treatment of erosive oesophagitis and other acid\u2010related diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the 4\u2010week healing rate and safety of four linaprazan glurate dosing regimens in patients with erosive oesophagitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This double\u2010blind, dose\u2010finding study compared linaprazan glurate to lansoprazole. We included patients with endoscopically confirmed erosive oesophagitis (validated by a central review board) if they had Los Angeles (LA) grade C\/D or LA grade A\/B with partial response to at least 8\u2009weeks of proton pump inhibitor therapy. Patients were randomised to 4\u2009weeks of linaprazan glurate (25, 50, 75 or 100\u2009mg twice daily) or lansoprazole (30\u2009mg once daily), followed by 4\u2009weeks of open\u2010label lansoprazole.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 248 patients randomised, central review confirmed erosive oesophagitis in 182 at screening endoscopy. Across all doses, linaprazan glurate achieved a 4\u2010week healing rate of 71.1% in intention\u2010to\u2010treat (ITT) analysis and 80.9% in per protocol (PP) analysis. In comparison, lansoprazole achieved healing rates of 60.6% (ITT) and 59.1% (PPS). The best performing linaprazan glurate dosing group outperformed lansoprazole by 28% in patients with LA grade A\/B with partial PPI response and by more than 50% in patients with LA grade C\/D.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Linaprazan glurate demonstrated high 4\u2010week healing rates compared to lansoprazole, with a good safety profile, supporting its further development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p>ClinicalTrials.gov: NCT05055128; EudraCT: 2020\u2010003319\u201091<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.70109","type":"journal-article","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T12:23:25Z","timestamp":1743855805000},"page":"1590-1602","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical Trial: Dose\u2010Finding Study of Linaprazan Glurate, A Novel Potassium\u2010Competitive Acid Blocker, Versus Lansoprazole for the Treatment of Erosive Oesophagitis"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5646-8727","authenticated-orcid":false,"given":"Prateek","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Gastroenterology University of Kansas School of Medicine  Leawood Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Vaezi","sequence":"additional","affiliation":[{"name":"Vanderbilt University  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Unge","sequence":"additional","affiliation":[{"name":"Cinclus Pharma Holding AB  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjell","family":"Andersson","sequence":"additional","affiliation":[{"name":"Cinclus Pharma Holding AB  Stockholm 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Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2487-1479","authenticated-orcid":false,"given":"David","family":"Armstrong","sequence":"additional","affiliation":[{"name":"McMaster University  Hamilton Ontario 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