{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:14:54Z","timestamp":1784542494960,"version":"3.55.0"},"reference-count":14,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011011","name":"Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["PI\u20100053\u20102018"],"award-info":[{"award-number":["PI\u20100053\u20102018"]}],"id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Faecal calprotectin is used to assess intestinal inflammation, but its role in monitoring mucosal healing in coeliac disease is unclear. This study followed 48 adults with coeliac disease on a gluten\u2010free diet over 12\u2009months, evaluating faecal calprotectin levels in correlation with anti\u2010transglutaminase antibodies, gluten\u2010free diet adherence by dietary questionnaires and histology. Although significant histological lesions (Marsh II\u2013III) decreased from 24% to 10%, faecal calprotectin levels fluctuated without correlation to anti\u2010transglutaminase, adherence or histological remission, and did not differentiate between lesion grades. Our findings underscore faecal calprotectin's unreliability in monitoring mucosal healing in adults with coeliac disease, highlighting the urgent need for alternative biomarkers.<\/jats:p>","DOI":"10.1111\/apt.70114","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T01:57:09Z","timestamp":1743731829000},"page":"1815-1819","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Limitations of Faecal Calprotectin in Detecting Histological Changes and Persistent Villous Atrophy in Patients With Coeliac Disease on a Gluten\u2010Free Diet"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9600-8979","authenticated-orcid":false,"given":"Ver\u00f3nica","family":"Segura","sequence":"first","affiliation":[{"name":"Department of Microbiology and Parasitology, Faculty of Pharmacy University of Seville  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7100-846X","authenticated-orcid":false,"given":"\u00c1ngela","family":"Ruiz\u2010Carnicer","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology, Faculty of Pharmacy University of Seville  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6317-1135","authenticated-orcid":false,"given":"\u00c1ngeles","family":"Pizarro","sequence":"additional","affiliation":[{"name":"Digestive Disease Clinical Unit and CIBERehd Institute of Biomedicine of Seville (IBiS), SeLiver Group, Virgen del Roc\u00edo Hospital\/CSIC\/US  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Gonz\u00e1lez\u2010Naranjo","sequence":"additional","affiliation":[{"name":"Digestive Disease Clinical Unit and CIBERehd Institute of Biomedicine of Seville (IBiS), SeLiver Group, Virgen del Roc\u00edo Hospital\/CSIC\/US  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacobo","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Clinical Analysis Service Hospital Universitario INGESA  Ceuta Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5598-0833","authenticated-orcid":false,"given":"Crist\u00f3bal","family":"Coronel\u2010Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Centro de Salud Amante Laff\u00f3n  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3646-8919","authenticated-orcid":false,"given":"Federico","family":"Arg\u00fcelles\u2010Arias","sequence":"additional","affiliation":[{"name":"Digestive Diseases Clinical Unit, Department of Medicine, Faculty of Medicine, Virgen Macarena Hospital University of Seville  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3522-3696","authenticated-orcid":false,"given":"Marta","family":"Garz\u00f3n\u2010Benavides","sequence":"additional","affiliation":[{"name":"Digestive Disease Clinical Unit and CIBERehd Institute of Biomedicine of Seville (IBiS), SeLiver Group, Virgen del Roc\u00edo Hospital\/CSIC\/US  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9235-9496","authenticated-orcid":false,"given":"Carolina","family":"Sousa","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology, Faculty of Pharmacy University of Seville  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4982-273X","authenticated-orcid":false,"given":"Isabel","family":"Comino","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology, Faculty of Pharmacy University of Seville  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010018\u20100054\u2010z"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2023-329751"},{"key":"e_1_2_9_4_1","first-page":"118","article-title":"The Role of Serology in the Diagnosis of Coeliac Disease","volume":"16","author":"Volta U.","year":"2023","journal-title":"Gastroenterology and Hepatology From Bed to Bench"},{"issue":"1","key":"e_1_2_9_5_1","first-page":"S49","article-title":"Review Article: Follow\u2010Up of Coeliac Disease","volume":"56","author":"Tye\u2010Din J. 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