{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T14:57:25Z","timestamp":1792421845205,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Chronic hepatitis C virus (HCV) infection is associated with hypolipidemia. HCV eradication may, therefore, result in hyperlipidemia and increase cardiovascular disease (CVD) risk. We investigated the impact of HCV eradication on serum lipid and lipoprotein profiles and CVD risk during and following direct\u2010acting antiviral (DAA) therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Approach and Results<\/jats:title><jats:p>We retrospectively analysed stored sera and plasma from 60 DAA\u2010na\u00efve patients, genotypes 1\u20134, treated with 12\u2009weeks of sofosbuvir\u2013velpatasvir. Serum lipids, apolipoproteins (apo), and a systemic inflammatory marker, GlycA, were measured serially beginning early on treatment and off treatment. Additionally, NMR LipoProfile analysis was performed on plasma samples. Expression of genes regulating lipid metabolism was assessed from paired liver biopsies obtained before and on treatment. Linear mixed models were used to examine changes in lipid and inflammatory markers; Framingham and ASCVD CVD risk scores were assessed before and after treatment. Decline in HCV viremia was associated with a rapid, significant increase in TChol, HDL\u2010C, LDL\u2010C, ApoA\u20101 and ApoB, and GlycA, improvement in ALT, hepatic inflammation, and steatosis but no change in glycemic control (HOMA\u2010IR and HbA1c). Increase in TChol, LDL\u2010C, and ApoB was associated with an increased SREBP1expression. Both ASCVD and Framingham risk scores were significantly increased at week 24 post treatment after adjusting for age (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum lipids and lipoproteins rapidly increase with inhibition of viral replication during <jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content> therapy, an effect that may be mediated by genes affecting hepatic de novo lipogenesis. Based on lipid changes, <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> eradication may increase <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content> risk, but this needs to be investigated prospectively.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.70130","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:35:22Z","timestamp":1747186522000},"page":"146-158","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clearance of Hepatitis C Viremia During Direct\u2010Acting Antiviral Therapy Leads to Rapid Changes in Lipid and Lipoprotein Metabolism"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7674-2305","authenticated-orcid":false,"given":"Zahra","family":"Sarrafan\u2010Chaharsoughi","sequence":"first","affiliation":[{"name":"Liver Diseases Branch NIDDK, NIH  Bethesda Maryland 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