{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:19:23Z","timestamp":1790140763918,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In randomised controlled trials, mirikizumab achieved clinical remission and improved outcomes of patients with moderate to severe ulcerative colitis (UC). However, there is currently no real\u2010world evidence for mirikizumab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the real\u2010world effectiveness and safety of mirikizumab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a retrospective cohort study among three facilities, we included patients with UC who first received mirikizumab between June 2023 and April 2024. The primary outcome was the change in the partial Mayo score (PMS) from week 0 to 12. Secondary outcomes included changes in serum C\u2010reactive protein (CRP) and leucine\u2010rich \u03b12\u2010glycoprotein (LRG) levels from week 0 to 12; clinical remission rate (PMS &lt;\u20092 with rectal bleeding subscore of 0), CRP remission rate (&lt;\u20093.0\u2009mg\/L), and LRG remission rate (&lt;\u200912.7\u2009\u03bcg\/mL) at week 12; and adverse events during induction therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 52 patients. Median (interquartile range) PMS decreased from week 0 to 12 (5 [3\u20136] to 2 [0\u20133], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). CRP and LRG levels also decreased (CRP: 3.8 [0.9\u20137.3] to 1.8 [0.5\u20134.0] mg\/L, <jats:italic>p<\/jats:italic>\u2009=\u20090.015; LRG: 20.1 [16.3\u201323.2] to 15.9 [12.8\u201323.2] \u03bcg\/mL, <jats:italic>p<\/jats:italic>\u2009=\u20090.014). Rates of clinical remission, CRP remission, and LRG remission at week 12 were 44.2%, 67.3%, and 27.3%, respectively. There were no adverse events leading to permanent discontinuation of mirikizumab or death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This real\u2010world study demonstrated the short\u2010term effectiveness and safety of mirikizumab in patients with UC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.70140","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T04:59:01Z","timestamp":1744261141000},"page":"1923-1934","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Real\u2010World Effectiveness and Safety of Mirikizumab Induction Therapy in Patients With Ulcerative Colitis: A Multicentre Retrospective Observational Study"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8310-9767","authenticated-orcid":false,"given":"Yasuhiro","family":"Takagi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, School of Medicine Hyogo Medical University  Nishinomiya Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8307-2445","authenticated-orcid":false,"given":"Toshiyuki","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, School of Medicine Hyogo Medical University  Nishinomiya Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Nishiguchi","sequence":"additional","affiliation":[{"name":"Center for Inflammatory Bowel Disease, Division of Gastroenterology Department of Internal Medicine, Tokyo Yamate Medical Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0706-0436","authenticated-orcid":false,"given":"Akira","family":"Nogami","sequence":"additional","affiliation":[{"name":"Center for Advanced IBD Research and Treatment Kitasato University Kitasato Institute Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8706-4231","authenticated-orcid":false,"given":"Masataka","family":"Igeta","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Hyogo Medical University  Nishinomiya Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichi","family":"Yagi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, School of Medicine Hyogo Medical University  Nishinomiya Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5816-5789","authenticated-orcid":false,"given":"Maiko","family":"Ikenouchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, School of Medicine Hyogo Medical University  Nishinomiya Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikio","family":"Kawai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, School of Medicine Hyogo Medical University  Nishinomiya Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Kamikozuru","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, School of Medicine Hyogo Medical University  Nishinomiya Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, School of Medicine Hyogo Medical University  Nishinomiya Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Tomita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, School of Medicine Hyogo Medical University  Nishinomiya Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Fukui","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, School of Medicine Hyogo Medical University  Nishinomiya Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8539-1594","authenticated-orcid":false,"given":"Masayuki","family":"Fukata","sequence":"additional","affiliation":[{"name":"Center for Inflammatory Bowel Disease, Division of Gastroenterology Department of Internal Medicine, Tokyo Yamate Medical Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2073-4234","authenticated-orcid":false,"given":"Taku","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Center for Advanced IBD Research and Treatment Kitasato University Kitasato Institute Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7051-618X","authenticated-orcid":false,"given":"Shinichiro","family":"Shinzaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, School of Medicine Hyogo Medical University  Nishinomiya Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32126-2"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40122-024-00672-9"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2024.1334308"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-024-00989-y"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-023-00768-1"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.122.001512"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2207940"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2023.00043"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1900750"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15717"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjab070"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/19420862.2021.1964420"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.02.004"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjw132"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535\u2010021\u201001793\u20100"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2023.00135"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izac230"},{"key":"e_1_2_11_19_1","unstructured":"FDA (FaDA). Center For Drug Evaluation and Research \u201cMirikizumab Prescribing Information \u201d2023 https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2023\/761279Orig1s000Lbl.pdf."},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-023-01281-z"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izz068"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-315671"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjae063"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.70140","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T06:47:15Z","timestamp":1748328435000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.70140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,9]]},"references-count":22,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/apt.70140"],"URL":"https:\/\/doi.org\/10.1111\/apt.70140","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,9]]},"assertion":[{"value":"2025-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}