{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T12:35:47Z","timestamp":1766579747982,"version":"3.41.0"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32GM118294","T32LM012415"],"award-info":[{"award-number":["T32GM118294","T32LM012415"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK122364"],"award-info":[{"award-number":["R01DK122364"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with inflammatory bowel disease (IBD) are often prescribed antispasmodics for chronic abdominal pain. Large\u2010scale data regarding efficacy and impact on clinical outcomes are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To examine the association between antispasmodic use and outcomes of abdominal pain and opioid use before and after propensity matching key demographic and clinical characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used TriNetX Diamond Network, a medical and claims database. Patients were stratified by baseline abdominal pain and opioid use. Secondary outcomes were corticosteroid use, IBD\u2010related complications and surgeries, emergency room (ER) visits, hospitalisation and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 85,859 patients (median age 50; 53.8% female) with IBD; 5661 used antispasmodics. On follow\u2010up, those with antispasmodic use had higher rates of abdominal pain and opioid use (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) regardless of baseline abdominal pain or opioid use. After matching, 5629 patients remained per group. Patients who used antispasmodics had higher rates of abdominal pain at 1\u2009month, regardless of baseline abdominal pain. Opioid\u2010na\u00efve patients who used antispasmodics had higher rates of opioid use at follow\u2010up (1.1% vs. 0.2%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The likelihood of corticosteroid use, clinic visits, ER visits and hospitalisation were higher in those with antispasmodic use. No differences in IBD\u2010related complications, surgery or mortality were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Antispasmodic use in patients with IBD was associated with increased abdominal pain and opioid use in opioid\u2010na\u00efve patients. Antispasmodic use was associated with increased likelihood of corticosteroid use, clinic and ER visits and hospitalisation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.70147","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T08:20:24Z","timestamp":1744359624000},"page":"1944-1956","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Impact of Antispasmodic Use on Abdominal Pain and Opioid Use in Inflammatory Bowel Disease: A Population\u2010Based Study"],"prefix":"10.1111","volume":"61","author":[{"given":"Chachrit","family":"Khunsriraksakul","sequence":"first","affiliation":[{"name":"Department of Medicine Johns Hopkins Hospital  Baltimore Maryland USA"},{"name":"Medical Scientist Training Program Penn State College of Medicine  Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2348-6683","authenticated-orcid":false,"given":"Olivia","family":"Ziegler","sequence":"additional","affiliation":[{"name":"Department of General Surgery Penn State College of Medicine  Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dajiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Penn State College of Medicine  Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey S.","family":"Kulaylat","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery Penn State College of Medicine  Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8976-5015","authenticated-orcid":false,"given":"Matthew D.","family":"Coates","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Penn State College of Medicine  Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,11]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_13_3_1","DOI":"10.1007\/s00384-020-03727-3"},{"doi-asserted-by":"publisher","key":"e_1_2_13_4_1","DOI":"10.1097\/01.MIB.0000195391.49762.89"},{"doi-asserted-by":"publisher","key":"e_1_2_13_5_1","DOI":"10.1097\/MIB.0b013e31829614c6"},{"doi-asserted-by":"publisher","key":"e_1_2_13_6_1","DOI":"10.1053\/j.gastro.2008.09.012"},{"doi-asserted-by":"publisher","key":"e_1_2_13_7_1","DOI":"10.1093\/ibd\/izx100"},{"key":"e_1_2_13_8_1","first-page":"167","article-title":"The Efficacy and Safety of Antispasmodic Agents in the Management of Irritable Bowel Syndrome: A Systematic Review","volume":"3","author":"Al Ghamdi K.","year":"2023","journal-title":"Journal of Health Science"},{"doi-asserted-by":"publisher","key":"e_1_2_13_9_1","DOI":"10.3748\/wjg.v20.i20.6031"},{"doi-asserted-by":"publisher","key":"e_1_2_13_10_1","DOI":"10.1016\/S2468-1253(20)30300-9"},{"doi-asserted-by":"publisher","key":"e_1_2_13_11_1","DOI":"10.1016\/S0002-9270(01)04037-0"},{"doi-asserted-by":"publisher","key":"e_1_2_13_12_1","DOI":"10.1038\/nrgastro.2010.4"},{"doi-asserted-by":"publisher","key":"e_1_2_13_13_1","DOI":"10.1016\/j.cgh.2018.08.001"},{"doi-asserted-by":"publisher","key":"e_1_2_13_14_1","DOI":"10.1136\/flgastro-2023-102471"},{"doi-asserted-by":"publisher","key":"e_1_2_13_15_1","DOI":"10.1093\/aje\/kwq433"},{"doi-asserted-by":"publisher","key":"e_1_2_13_16_1","DOI":"10.1001\/jamanetworkopen.2021.45876"},{"doi-asserted-by":"publisher","key":"e_1_2_13_17_1","DOI":"10.1002\/ibd.20848"},{"doi-asserted-by":"publisher","key":"e_1_2_13_18_1","DOI":"10.1053\/j.gastro.2022.04.016"},{"doi-asserted-by":"publisher","key":"e_1_2_13_19_1","DOI":"10.14309\/ajg.0000000000001266"},{"doi-asserted-by":"publisher","key":"e_1_2_13_20_1","DOI":"10.1093\/annonc\/mdi922"},{"doi-asserted-by":"publisher","key":"e_1_2_13_21_1","DOI":"10.1038\/ajg.2009.71"},{"doi-asserted-by":"publisher","key":"e_1_2_13_22_1","DOI":"10.1016\/j.cgh.2017.05.014"},{"doi-asserted-by":"publisher","key":"e_1_2_13_23_1","DOI":"10.1111\/nmo.14645"},{"doi-asserted-by":"publisher","key":"e_1_2_13_24_1","DOI":"10.14309\/ajg.0000000000001306"},{"doi-asserted-by":"publisher","key":"e_1_2_13_25_1","DOI":"10.1093\/crocol\/otad055"}],"container-title":["Alimentary Pharmacology &amp; 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