{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T18:51:13Z","timestamp":1788461473643,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Inflammatory bowel diseases (\n                      <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>\n                      ) have been associated with an increased long\u2010term risk of coronary artery disease due to chronic systemic inflammation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the risk of major adverse cardiovascular events (MACE) after coronary interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this nationwide cohort study of adults undergoing percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) (2012\u20132022), patients with IBD were propensity score\u2010matched 1:10 to comparators without IBD. The primary outcome was MACE, a composite of acute myocardial infarction, stroke, hospitalisation for heart failure, or mortality. Secondary outcomes included each MACE component, 30\u2010day all\u2010cause readmission, revascularisation and in\u2010hospital outcomes including intensive care unit admission and length of hospital stay. We calculated hazard ratios (HRs) and incidence rates (IRs) using Cox proportional hazards modelling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 987 patients with IBD and 9571 matched comparators. After a median follow\u2010up of 3.5 years, MACE occurred in 488 patients with IBD (49.4%, IR: 96.5\/10,000 person\u2010years [PY]) and in 3857 matched comparators (40.3%, IR: 68.9\/10,000 PY); HR 1.37 (95% CI, 1.24\u20131.52). This equates to one additional MACE for every 36 patients with IBD over 10 years. The risk of each MACE component was increased, except for stroke. There were no differences between IBD subtypes or coronary intervention (PCI\n                      <jats:italic>vs.<\/jats:italic>\n                      CABG). Risks were highest in older individuals and elective interventions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with IBD were at 37% higher risk of MACE after coronary intervention, indicating a need for intensified cardiovascular risk reduction in these high\u2010risk individuals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70162","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T06:49:02Z","timestamp":1745909342000},"page":"1904-1912","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Increased Risk of Cardiovascular Events After Coronary Interventions in Inflammatory Bowel Disease: A Nationwide Matched Cohort Study"],"prefix":"10.1111","volume":"61","author":[{"given":"Ramin","family":"Ebrahimi","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine B University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5862-966X","authenticated-orcid":false,"given":"Fahim","family":"Ebrahimi","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Gastroenterology and Hepatology University Digestive Health Care Center Basel\u2013Clarunis  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6902-5650","authenticated-orcid":false,"given":"Jan Hendrik","family":"Niess","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Digestive Health Care Center Basel\u2013Clarunis  Basel Switzerland"},{"name":"Department of Biomedicine, Gastroenterology Group University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Mahdi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Solna, Karolinska Institutet Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7082-9573","authenticated-orcid":false,"given":"Shaojie","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine B University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Di Vece","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine B University Medicine Greifswald  Greifswald Germany"},{"name":"First Clinic of 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