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We analysed long\u2010term outcomes of patients in sustained clinical remission from the start of EXIT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 125 patients (63 in MA and 62 in WA). Median follow\u2010up was 12\u2009months for MA and 26\u2009months for WA. The cumulative incidence of relapse (95% CI) was 35% (23%\u201348%) in MA and 47% (34%\u201360%) in WA; <jats:italic>p<\/jats:italic>\u2009=\u20090.3. In MA, relapses occurred in 8% of patients by 12\u2009months and 47% by 24\u2009months. In WA, relapses occurred in 16% by 12\u2009months and 39% by 24\u2009months. The incidence rate of relapse per patient\u2010year was 22% in MA and 19% in WA. Baseline faecal calprotectin &gt;\u2009250\u2009\u03bcg\/g was the only variable associated with a higher risk of relapse. Of the 29 patients who relapsed in WA, 26 (90%) resumed anti\u2010TNF therapy; of these, 69% regained clinical remission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this extended analysis of patients included in the EXIT trial, withdrawing anti\u2010TNF therapy in patients with IBD in remission was not associated with a higher long\u2010term relapse risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.70172","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T08:26:20Z","timestamp":1746174380000},"page":"59-71","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Long\u2010Term Outcomes Following Withdrawal of Anti\u2010Tumour Necrosis Factor Treatment in Inflammatory Bowel Disease Patients in Remission: The Exit Long\u2010Term Study of GETECCU"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8233-9638","authenticated-orcid":false,"given":"Mar\u00eda Jos\u00e9","family":"Casanova","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS\u2010Princesa), and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD) Universidad Aut\u00f3noma de Madrid (UAM)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3611-8994","authenticated-orcid":false,"given":"Cristina","family":"Rub\u00edn de C\u00e9lix","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS\u2010Princesa), and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD) Universidad Aut\u00f3noma de Madrid (UAM)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9383-3698","authenticated-orcid":false,"given":"Sabino","family":"Riestra","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, e Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA) Hospital Universitario Central de Asturias  Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1183-1072","authenticated-orcid":false,"given":"Alfredo J.","family":"Lucendo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Instituto de Investigaci\u00f3n Sanitaria de Castilla\u2010La Mancha (IDISCAM) Hospital General de Tomelloso, CIBEREHD  Tomelloso Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel","family":"Ben\u00edtez","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC) Hospital Universitario Reina Sof\u00eda  C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merc\u00e8","family":"Navarro\u2010Llavat","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital de Sant Joan Desp\u00ed Mois\u00e8s Broggi  Sant Joan Desp\u00ed Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Barrio","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Gerencia Regional de Salud de Castilla y Le\u00f3n (SACYL) Hospital Universitario R\u00edo Hortega  Valladolid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctor J.","family":"Morales\u2010Alvarado","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital General de Granollers  Granollers Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Rivero","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Instituto de Investigaci\u00f3n Sanitaria Valdecilla (IDIVAL) Hospital Universitario Marqu\u00e9s de Valdecilla  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Busquets","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitari Girona Dr. J. 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