{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T18:37:14Z","timestamp":1775241434487,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Alpha\u20101 antitrypsin deficiency (AATD) is a prevalent genetic disorder in Europe causing hepatic fibrosis and often remains undiagnosed, even in severe cases requiring liver transplantation (LT). This study aimed to determine the frequency of pre\u2010LT diagnosis amongst LT candidates with AATD and to describe their clinical characteristics. A secondary goal was to assess awareness and practices concerning AATD amongst LT specialists in France.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective multicenter cohort study included LT candidates diagnosed with AATD based on PAS\u2010positive staining of explanted livers (1995\u20132020) from nine centres in France and Canada. A 22\u2010question survey was sent to LT specialists in France to assess AATD knowledge and practices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Amongst 58 patients diagnosed with AATD between 1996 and 2020, 40% were diagnosed pre\u2010LT, 15% post\u2010LT and 45% never confirmed. Less than 25% had non\u2010specific pulmonary symptoms. The survey revealed poor awareness of AATD; 78% of specialists rated their knowledge as very low to moderate. Consistent pre\u2010LT screening occurred in 59.3% of cases, and 52.5% recommended familial screening upon a confirmed diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>AATD remains underdiagnosed in pre\u2010LT assessments and is poorly understood amongst practitioners in France. Improved screening can enhance patient management, especially with emerging potentially curative treatments.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.70183","type":"journal-article","created":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T00:58:44Z","timestamp":1748653124000},"page":"193-203","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Underdiagnosis of Alpha\u20101 Antitrypsin Deficiency in Cirrhotic Liver Transplant Candidates: Findings From a Multicenter Retrospective Study"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9409-2887","authenticated-orcid":false,"given":"Manon","family":"Evain","sequence":"first","affiliation":[{"name":"AP\u2010HP H\u00f4pital Paul Brousse, Centre H\u00e9pato\u2010Biliaire, Paris\u2010Saclay University  Villejuif France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3711-1287","authenticated-orcid":false,"given":"Isaac","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Liver Transplantation, Centre Hospitalier de l'Universite of Montr\u00e9al  Montreal Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Antonini","sequence":"additional","affiliation":[{"name":"The Lyon liver institute, Everest IHU Hepatology Department, Croix Rousse Hospital, Hospices Civils of Lyon, Lyon, France  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Lassailly","sequence":"additional","affiliation":[{"name":"Service des Maladies de l'Appareil Digestif, Centre Hospitalier Universitaire de Lille (CHU de Lille), Lille, France; European Genomic Institute for Diabetes (EGID), UMR 1190 Translational Research for Diabetes, Inserm, CHU Lille, University of Lille  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Mazzola","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9pato\u2010gastroent\u00e9rologie, H\u00f4pital La Piti\u00e9 Salp\u00eatri\u00e8re  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline Houssel","family":"Debry","sequence":"additional","affiliation":[{"name":"Service des maladies du foie  CHU Rennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laure","family":"Elkrief","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de m\u00e9decine de Tours et CHRU de Tours, service d'h\u00e9pato\u2010gastroent\u00e9rologie, centre de r\u00e9f\u00e9rence constitutif Maladies Vasculaires du foie, Filfoie, ERN Rare Liver  Tours France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodolphe","family":"Anty","sequence":"additional","affiliation":[{"name":"Archet 2 University hospital, Inserm U1065 team 8, universit\u00e9 C\u00f4te d\u2019Azur  Nice France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myl\u00e8ne","family":"Sebagh","sequence":"additional","affiliation":[{"name":"AP\u2010HP H\u00f4pital Paul Brousse, Centre H\u00e9pato\u2010Biliaire, Paris\u2010Saclay University  Villejuif France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Ichai","sequence":"additional","affiliation":[{"name":"AP\u2010HP H\u00f4pital Paul Brousse, Centre H\u00e9pato\u2010Biliaire, Paris\u2010Saclay University  Villejuif France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Cherqui","sequence":"additional","affiliation":[{"name":"AP\u2010HP H\u00f4pital Paul Brousse, Centre H\u00e9pato\u2010Biliaire, Paris\u2010Saclay University  Villejuif 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