{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T08:06:16Z","timestamp":1776413176918,"version":"3.51.2"},"reference-count":5,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>We performed a re\u2010analysis of the gastrointestinal risks of glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101 RA) in obese US adult patients without diabetes using the TriNetX database (GLP\u20101 RA <jats:italic>n<\/jats:italic>\u2009=\u20098792; Bupropion\u2010naltrexone <jats:italic>n<\/jats:italic>\u2009=\u20098792) after accounting for initial BMI. GLP\u20101 RA users had higher risks of gastroparesis (aHR 2.30; 95% CI 1.19\u20134.46) and biliary disease (aHR 1.27; 95% CI 0.96\u20131.39) but did not have a conclusively elevated risk of acute pancreatitis or obstruction. Not matching for BMI suggested an elevated pancreatitis risk (aHR 1.75; 95% CI 1.13\u20132.70). Semaglutide conferred superior weight loss but increased biliary risk.<\/jats:p>","DOI":"10.1111\/apt.70190","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T04:04:38Z","timestamp":1747109078000},"page":"77-80","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Some Risks of Gastrointestinal Adverse Events Associated With Glucagon\u2010Like PEPTIDE\u20101 Receptor Agonists Are Likely Explained by BMI"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2089-7607","authenticated-orcid":false,"given":"Benjamin Douglas","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Medicine MetroHealth Medical Center, Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donovan","family":"Veccia","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology MetroHealth Medical Center, Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Medicine MetroHealth Medical Center, Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gengqing","family":"Song","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology MetroHealth Medical Center, Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.19574"},{"key":"e_1_2_9_3_1","unstructured":"ICH \u201cMedical Dictionary for Regulatory Activities (MedDRA) Version 22.0 \u201d(2024) https:\/\/www.meddra.org."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2014.01.010"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eprac.2021.12.007"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2022.0338"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.70190","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T12:48:42Z","timestamp":1754916522000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.70190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,13]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/apt.70190"],"URL":"https:\/\/doi.org\/10.1111\/apt.70190","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,13]]},"assertion":[{"value":"2025-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}