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However, these behavioural interventions alone may not achieve disease regression or remission, and maintaining long\u2010term adherence is challenging. Incretin mimetics and other gastrointestinal hormones targeting the pleiotropic pathophysiological pathways underlying MASLD have now emerged as promising disease\u2010modifying therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This is a comprehensive review summarising the role of glucagon\u2010like peptide\u20101 (GLP\u20101) receptor agonists and glucagon\/glucose\u2010dependent insulinotropic polypeptide (GIP)\/GLP\u20101 receptor dual or triple agonists in the treatment of metabolic dysfunction\u2010associated steatohepatitis (MASH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Only clinical trials with endpoints assessed by liver histology were included for a robust evaluation of therapeutic efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Recent evidence from phase 2 clinical trials for MASH demonstrated that pharmacological agents based on GLP\u20101 receptor agonism are effective in improving disease activity. Additionally, tirzepatide and survodutide showed potential clinical benefits in reducing fibrosis. Other cardiometabolic benefits observed include weight loss and improvements in glycaemic control and lipid profile. Adherence to treatment may be limited by gastrointestinal side effects, though they were found to be generally mild to moderate in severity. An interim analysis of the semaglutide phase 3 trial confirmed its efficacy in improving steatohepatitis and demonstrated its potential to improve fibrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GLP\u20101 receptor agonists, alone or in combination with GIP and\/or glucagon receptor agonists, represent promising, effective pharmacotherapies for the treatment of MASLD\/MASH. Larger and longer\u2010duration clinical trials are needed to further evaluate the efficacy and safety of GIP receptor and glucagon receptor agonism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70196","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:39:26Z","timestamp":1747186766000},"page":"1872-1888","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Review Article:\n                    <scp>GLP<\/scp>\n                    \u20101 Receptor Agonists and Glucagon\/\n                    <scp>GIP<\/scp>\n                    \/\n                    <scp>GLP<\/scp>\n                    \u20101 Receptor Dual or Triple Agonists\u2014Mechanism of Action and Emerging Therapeutic Landscape in\n                    <scp>MASLD<\/scp>"],"prefix":"10.1111","volume":"61","author":[{"given":"Maryam","family":"Zafer","sequence":"first","affiliation":[{"name":"MASLD Research 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