{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:15:56Z","timestamp":1792026956893,"version":"4.4.0"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>While three Janus kinase inhibitors (JAKi) have demonstrated efficacy in ulcerative colitis (UC), scarce data exist regarding JAKi intraclass switching.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the effectiveness and safety of a second JAK inhibitor in UC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a multicentre, retrospective, observational cohort including patients with moderate to severe UC who received a second\u2010line of JAKi after failure or intolerance of a first. The primary outcome was steroid\u2010free clinical remission (SFCR) at Weeks 8\u201314, defined as a partial Mayo score of 2 or less with no individual sub\u2010score above 1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 169 patients from 28 participating centres, 105 received upadacitinib, 54 filgotinib and 10 tofacitinib as a second\u2010line of JAKi. Overall, 81\/169 achieved SFCR at Weeks 8\u201314: 58\/105 with upadacitinib, 18\/54 with filgotinib and 5\/10 with tofacitinib (<jats:italic>p<\/jats:italic>\u2009=\u20090.03). In the multivariate analysis, upadacitinib was independently associated with higher odds of SFCR than filgotinib (OR\u2009=\u20093.15, 95% CI [1.52\u20136.79]). With a median follow\u2010up duration of 96\u2009days, drug persistence at 6\u2009months was 72.8% with upadacitinib, 57.2% with filgotinib and 66.7% with tofacitinib (<jats:italic>p<\/jats:italic>\u2009=\u20090.099). 24.3% of patients (41\/169) experienced at least one adverse event leading to treatment withdrawal in 9 patients (5%). No cases of death, cancer, or major acute cardiovascular events were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A second\u2010line of JAKi provided clinical remission in about half of patients after induction, and was well tolerated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.70199","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T03:49:54Z","timestamp":1747885794000},"page":"430-439","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Effectiveness and Safety of a Second <scp>JAK<\/scp> Inhibitor in Ulcerative Colitis: The <scp>J2J<\/scp> Multicentre Study"],"prefix":"10.1111","volume":"62","author":[{"given":"Mathilde","family":"Osty","sequence":"first","affiliation":[{"name":"Gastroenterology Department H\u00f4pital Henri Mondor, APHP  Cr\u00e9teil 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Department CH Valenciennes  Valenciennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Cadiot","sequence":"additional","affiliation":[{"name":"Gastroenterology Department CHU de Reims, Facult\u00e9 de M\u00e9decine de Reims  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucine","family":"Vuitton","sequence":"additional","affiliation":[{"name":"Gastroenterology Department CHU de Besan\u00e7on  Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Wampach","sequence":"additional","affiliation":[{"name":"Service de Gastroent\u00e9rologie et Endoscopies Digestives H\u00f4pital Europ\u00e9en Georges Pompidou, APHP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Nancey","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, CH Lyon\u2010Sud, Hospices Civils de Lyon Universit\u00e9 Claude 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