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Mepolizumab had significantly lower HSS vs. placebo for both grade (0.39\u2009\u00b1\u20090.14 vs. 0.56\u2009\u00b1\u20090.21; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and stage (0.37\u2009\u00b1\u20090.14 vs. 0.53\u2009\u00b1\u20090.20; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). HSS correlated with endoscopic severity for grade (<jats:italic>R<\/jats:italic>\u2009=\u20090.45, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and stage (<jats:italic>R<\/jats:italic>\u2009=\u20090.47, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), but improvement was primarily limited to the eosinophil\u2010dependent HSS features. Eosinophil\u2010focused treatments alone may not provide comprehensive treatment response across multiple outcome domains in EoE.<\/jats:p>","DOI":"10.1111\/apt.70216","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T01:50:47Z","timestamp":1748569847000},"page":"453-457","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Research Communication: Mepolizumab Improves Histologic Severity as Measured by the <scp>EoEHSS<\/scp> in Adolescents and Adults With Eosinophilic Oesophagitis in a Multicenter, Randomised, Double\u2010Blind, Placebo\u2010Controlled Clinical Trial"],"prefix":"10.1111","volume":"62","author":[{"given":"Joseph L.","family":"Maniaci","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of North Carolina School of Medicine  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Iuga","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of North Carolina School of Medicine  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine E.","family":"Bookhout","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of North Carolina School of Medicine  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay M.","family":"Cortright","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Center for Esophageal Diseases and Swallowing, and Center for Gastrointestinal Biology and Disease University of North Carolina School of Medicine  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kacie B.","family":"Walker","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Center for Esophageal Diseases and Swallowing, and Center for Gastrointestinal Biology and Disease University of North Carolina School of Medicine  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan E.","family":"Moist","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Center for Esophageal Diseases and Swallowing, and Center for Gastrointestinal Biology and Disease University of North Carolina School of Medicine  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1793-6027","authenticated-orcid":false,"given":"Kathryn A.","family":"Peterson","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin L.","family":"Mitlyng","sequence":"additional","affiliation":[{"name":"MNGI Digestive Health  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1167-1101","authenticated-orcid":false,"given":"Evan S.","family":"Dellon","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Center for Esophageal Diseases and Swallowing, and Center for Gastrointestinal Biology and Disease University of North Carolina School of Medicine  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.09.004"},{"key":"e_1_2_9_3_1","first-page":"1","article-title":"Newly Developed and Validated Eosinophilic Esophagitis Histology Scoring System and Evidence That It Outperforms Peak Eosinophil Count for Disease Diagnosis and Monitoring","volume":"30","author":"Collins M. H.","year":"2017","journal-title":"Diseases of the Esophagus"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002637"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001361"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2313318"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.178558"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.07.044"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2023-330337"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.08.028"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-009-1005-z"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.70216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T09:01:51Z","timestamp":1753347711000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.70216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,29]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1111\/apt.70216"],"URL":"https:\/\/doi.org\/10.1111\/apt.70216","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,29]]},"assertion":[{"value":"2025-03-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}