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We searched MEDLINE, Embase and Embase Classic (via Ovid) from inception until 28th February 2025. Clinical trials, cohort, case\u2013control, cross\u2010sectional and case series studies were eligible for inclusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 28 studies on AI in EoE, with 18 focusing on diagnosis. AI was used for histology image analysis in digital pathology in seven and endoscopic image analysis in three studies. AI\u2010based non\u2010invasive diagnostic predictive models showed high accuracy in detecting EoE. As a prognostic tool, AI showed potential in predicting food impaction, histologic disease severity and fibrosis. AI was used in precision medicine for biomarker discovery, endotype prediction based on transcriptomics and treatment personalisation, as well as in disease monitoring and follow\u2010up. Unmet needs included insufficient studies on children\/adolescents, prediction of treatment response and improvement of study designs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although AI showed promise at improving EoE management across various domains, most tools require validation on larger, independent and prospective cohorts. Several challenges, including algorithmic bias, data privacy, explainability and regulatory hurdles, need to be addressed for clinical implementation. Future studies should focus on developing non\u2010invasive diagnostic tools for younger populations, treatment response prediction and disease monitoring.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.70222","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T02:24:08Z","timestamp":1749176648000},"page":"110-127","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Systematic Review: Use of Artificial Intelligence and Unmet Needs in Eosinophilic Oesophagitis"],"prefix":"10.1111","volume":"62","author":[{"given":"Ester","family":"Castagnaro","sequence":"first","affiliation":[{"name":"Department of Medicine and Surgery University of Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Felici","sequence":"additional","affiliation":[{"name":"Pediatric and Pediatric Emergency Unit Children Hospital, AOU SS Antonio e Biagio e C. 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