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It is especially prevalent in haematologic malignancies, complicating treatment regimens and posing a risk for severe outcomes such as acute liver failure. Antibody\u2010based therapies have significantly improved treatment outcomes. However, these therapies are increasingly associated with liver injury, posing challenges in clinical management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This review aims to examine the DILI associated with antibody\u2010based therapies in haematologic malignancies, highlighting key mechanisms, risk factors, clinical management strategies, and identifying areas that require further research.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a comprehensive review of the literature on DILI induced by antibody\u2010based therapies, including monoclonal antibodies, antibody\u2010drug conjugates, and T\u2010cell redirecting antibodies, specifically in the context of haematologic malignancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>DILI associated with antibody\u2010based therapies varies from mild transaminase elevations to severe liver injury. Risk factors include pre\u2010existing liver disease, genetic predisposition, and therapy\u2010specific mechanisms such as immune\u2010mediated liver damage or direct hepatotoxic effects. Current management strategies involve routine liver function monitoring, dose modifications, and therapy discontinuation in severe cases. However, standardised guidelines remain lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>DILI remains a major challenge in the use of antibody\u2010based therapies for haematologic malignancies. While progress has been made in understanding risk factors and management strategies, further research is essential to optimise patient care and balance therapeutic efficacy with liver toxicity risks.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.70228","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T01:16:08Z","timestamp":1750900568000},"page":"300-318","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Review Article: Drug\u2010Induced Liver Injury Associated With Antibody\u2010Based Therapies in Haematologic Malignancies"],"prefix":"10.1111","volume":"62","author":[{"given":"Mengmeng","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaping","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Hematology Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University  Zhejiang Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahe","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Medicine Hangzhou City University  Zhejiang Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Shi","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nengming","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangmin","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Hematology Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University  Zhejiang Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.18271"},{"key":"e_1_2_13_3_1","unstructured":"CIOMS \u201cWorking Group on Drug\u2010Induced Liver Injury (DILI): Consensus Report \u201d[EB\/OL] (2025) accessed March 26 2025 https:\/\/cioms.ch\/publications\/product\/drug\u2010induced\u2010liver\u2010injury\/."},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-022-01185-0"},{"key":"e_1_2_13_5_1","first-page":"1","article-title":"Drug Withdrawal due to Safety: A Review of the Data Supporting Withdrawal Decision","volume":"15","author":"Craveiro N. 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