{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T08:55:17Z","timestamp":1758704117747,"version":"3.43.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T00:00:00Z","timestamp":1749254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K76AG083309"],"award-info":[{"award-number":["K76AG083309"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although depression is prevalent among people with inflammatory bowel diseases (IBD), the impact of treating depression is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective study in an electronic\u2010health record\u2010based cohort. We identified patients with IBD using \u2265\u20092 diagnosis codes, and patients with depression using \u2265\u20091 diagnosis code. The exposure was a medication for the treatment of IBD. We assessed IBD\u2010related hospitalizations, surgery, and emergency room (ER) visits after the index date of depression code or initiation of depression medication. We constructed multivariable logistic regression models to determine the odds of the outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 4052 patients with IBD and depression with a median age of 49\u2009years. In this cohort, 39% did not receive medication for depression while 61% were treated with an antidepressant not commonly prescribed for pain. Patients with IBD treated for depression were less likely to have an IBD\u2010related ER visit than patients with IBD and depression not treated for depression (aOR: 0.63, 95% CI: 0.44\u20130.90). However, patients who were treated for depression were also more likely to be hospitalised (aOR: 1.40, 95% CI: 1.20\u20131.62), be treated with a corticosteroid (aOR: 1.34, 95% CI: 1.16\u20131.55) and have surgery for IBD (aOR: 1.42, 95% CI: 1.17\u20131.71).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Antidepressant use is associated with reduced ER utilisation in patients with IBD. There were also increased hospitalisations, corticosteroid treatment, and surgery, which may reflect a more aggressive disease course associated with depression. Treating depression in patients with IBD may reduce healthcare costs by decreasing ER visits.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.70229","type":"journal-article","created":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T06:20:44Z","timestamp":1749277244000},"page":"536-542","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Outcomes Associated With Anti\u2010Depressant Use in Patients With Inflammatory Bowel Disease"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8862-1236","authenticated-orcid":false,"given":"Bharati","family":"Kochar","sequence":"first","affiliation":[{"name":"Gastroenterology Unit Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"The Mongan Institute  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara","family":"Chaaban","sequence":"additional","affiliation":[{"name":"Department of Medicine Johns Hopkins Hospital  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn","family":"Kobeissi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Fuss","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prasanna","family":"Challa","sequence":"additional","affiliation":[{"name":"The Mongan Institute  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Melia","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9436-1821","authenticated-orcid":false,"given":"Ashwin","family":"Ananthakrishnan","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"The Mongan Institute  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00014-5"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.17058"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-317182"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12195"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.12.045"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2017.423"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/ebmental-2020-300223"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.01.027"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12669"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2022.110719"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.07.025"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(16)30206-0"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S106039"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/1735-1995.165969"},{"key":"e_1_2_8_16_1","first-page":"509","article-title":"Fluoxetine for Maintenance of Remission and to Improve Quality of Life in Patients With Crohn's Disease: A Pilot Randomized Placebo\u2010Controlled Trial","volume":"11","author":"Mikocka\u2010Walus A.","year":"2017","journal-title":"Journal of Crohn's & Colitis"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21846"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2047242"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16820"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e31828133fd"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.2196\/43005"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2024.1778"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-022-00634-6"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.07.003"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.10.017"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izab074"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.09.012"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000001121"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.16568"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2021.1911644"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14226"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/jcag\/gwad020"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0259-y"},{"key":"e_1_2_8_34_1","first-page":"353","article-title":"In Vitro Immunoregulatory Effects of Antidepressants in Healthy Volunteers","volume":"55","author":"Szuster\u2010Ciesielska A.","year":"2003","journal-title":"Polish Journal of Pharmacology"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-51282-6"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e318281f395"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.07.002"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000002768"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2024.04.017"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.04.007"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.70229","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T22:56:49Z","timestamp":1755039409000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.70229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,7]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/apt.70229"],"URL":"https:\/\/doi.org\/10.1111\/apt.70229","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"type":"print","value":"0269-2813"},{"type":"electronic","value":"1365-2036"}],"subject":[],"published":{"date-parts":[[2025,6,7]]},"assertion":[{"value":"2025-02-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}