{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T14:37:05Z","timestamp":1778164625835,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hepatitis delta virus (HDV) requires hepatitis B virus (HBV) surface antigen to enter hepatocytes. Although HBV\/HDV coinfection is the most severe form of viral hepatitis, disease progression and liver\u2010related data are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the characteristics of studies reporting HDV outcomes and the incidence of liver\u2010related events among individuals with HDV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched online databases from 1 January 2000 to 14 December 2022 and congress proceedings from 2021 to 2022. Randomised controlled trials (RCTs), non\u2010randomised interventional studies and observational studies reporting incidence of cirrhosis, hepatic decompensation, hepatocellular carcinoma (HCC), liver transplant (LT) and liver\u2010related death in \u2265\u200920 adults with active HDV infection were included. Study\/participant characteristics, cumulative incidence and incidence rates were extracted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data were extracted from 32 unique studies in 47 publications. While most (<jats:italic>n<\/jats:italic>\u2009=\u200919; 59%) studies included &lt;\u2009100 individuals, five included \u2265\u2009200. Most were retrospective cohort (<jats:italic>n<\/jats:italic>\u2009=\u200919; 59%), and the remainder were prospective cohort (<jats:italic>n<\/jats:italic>\u2009=\u20095), non\u2010randomised interventional (<jats:italic>n<\/jats:italic>\u2009=\u20093), RCT (<jats:italic>n<\/jats:italic>\u2009=\u20093) or registry\/database studies (<jats:italic>n<\/jats:italic>\u2009=\u20092). Outcomes reported by the largest numbers of studies were hepatic decompensation (<jats:italic>n<\/jats:italic>\u2009=\u200921) and HCC (<jats:italic>n<\/jats:italic>\u2009=\u200920); the least reported was cirrhosis (<jats:italic>n<\/jats:italic>\u2009=\u20099). Heterogeneity existed in participant populations, with variability in baseline markers of liver disease severity. Consequently, a wide range of cumulative incidence values was observed (cirrhosis, 0%\u201363%; hepatic decompensation, 0%\u201352%; HCC, 0%\u201319%; LT, 2%\u201343%; liver\u2010related death, 0%\u201319%; composite endpoint, 3%\u201374%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The number of studies describing the incidence of liver\u2010related outcomes among people with HDV remains limited. Quantifying incidence of liver\u2010related events can improve our understanding of disease progression and inform potential treatment strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p>PROSPERO registration ID: CRD42023386845<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.70251","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T12:50:39Z","timestamp":1752065439000},"page":"389-399","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Systematic Review: Incidence of Liver\u2010Related Events in People Living With Hepatitis Delta Virus"],"prefix":"10.1111","volume":"62","author":[{"given":"Laura E.","family":"Telep","sequence":"first","affiliation":[{"name":"Gilead Sciences, Inc.  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