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In a case\u2013control study using the inpatient datafile of the Centres for Medicare and Medicaid Services (CMS), we examined the concurrence of CP or CRC with non\u2010erosive reflux disease (NERD), erosive oesophagitis (EE), Barrett's oesophagus (BE) and eosinophilic oesophagitis (EoE) in identical patients. The total CMS population comprised 6,462,321 individual patients. CP and CRC were significantly associated with EE, NERD and BE. Our results suggest that reflux disease is associated with an increased risk for colonic neoplasia.<\/jats:p>","DOI":"10.1111\/apt.70268","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T04:47:33Z","timestamp":1751604453000},"page":"837-840","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Research Communication: Reflux Disease May Constitute a Risk Factor for Colonic Neoplasia"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5986-7042","authenticated-orcid":false,"given":"Amnon","family":"Sonnenberg","sequence":"first","affiliation":[{"name":"Section of Gastroenterology Portland VA Medical Center  Oregon Portland USA"},{"name":"Division of Gastroenterology and Hepatology Oregon Health &amp; Science University  Oregon Portland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna M.","family":"Buchner","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Kohen","sequence":"additional","affiliation":[{"name":"Unaffiliated"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-017-4841-2"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp2114026"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.14968"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw2367"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djw322"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2023.11.040"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-013-2565-5"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000127"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.09.008"},{"issue":"1","key":"e_1_2_9_11_1","first-page":"S1","article-title":"Epidemiology of Helicobacter pylori","volume":"55","author":"Sonnenberg A.","year":"2022","journal-title":"Alimentary Pharmacology & Therapeutics"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.70268","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T23:52:44Z","timestamp":1758585164000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.70268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,4]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/apt.70268"],"URL":"https:\/\/doi.org\/10.1111\/apt.70268","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,4]]},"assertion":[{"value":"2025-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}