{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T08:16:51Z","timestamp":1788337011525,"version":"build-2803163510"},"reference-count":80,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Autoimmune hepatitis (AIH) may be difficult to diagnose and distinguish clinically and biochemically from other chronic liver diseases like metabolic dysfunction\u2010associated steatotic liver disease (MASLD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To identify pathways involved in the pathogenesis and identify disease\u2010specific biomarkers of AIH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 19 newly diagnosed patients with AIH, 17 with MASLD, and 19 healthy controls. Liver tissue and plasma were collected, and untargeted mass\u2010spectrometry\u2010based proteomics was performed. For classification of AIH versus MASLD and healthy, machine learning analyses were performed employing logistic regression models on liver and plasma proteome data. Findings were validated using data from the United Kingdom Biobank (UKB).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 7632 liver and 556 plasma proteins with 2521 liver and 227 plasma proteins differing between AIH and healthy, including 56 overlapping. Metabolic dysregulation and systemic immune activation characterised the AIH liver and plasma proteome, respectively. Plasma proteome profiling enabled classification of AIH from MASLD and healthy with an area under the receiver operating characteristic curve of 0.91 (0.09 SD). Validation in the UKB was possible for 8 of 20 diagnostic proteins and showed consistent directional changes. Three proteins (C7, ICAM1, cAST) were significantly different between AIH and MASLD\/healthy in unadjusted analyses, and 6 of 8 proteins (C7, ICAM1, cAST, IGFBP3, TIMP1, TTR) were significantly different when adjusting for age and sex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Clinical proteomic analyses of paired liver\u2010plasma samples from patients with AIH enabled high diagnostic potential. Proteomics may constitute a novel non\u2010invasive diagnostic tool for AIH if validated in larger, age\u2010 and sex\u2010matched cohorts.<\/jats:p><jats:p><jats:bold>Clinical Trial Number:<\/jats:bold> <jats:styled-content style=\"fixed-case\">NCT05335603<\/jats:styled-content><\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.70273","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T07:10:37Z","timestamp":1752736237000},"page":"901-919","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Diagnostics of Autoimmune Hepatitis Enabled by Non\u2010Invasive Clinical Proteomics"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5982-8684","authenticated-orcid":false,"given":"Anne\u2010Sofie Houlberg","family":"Jensen","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry Copenhagen University Hospital\u2014Bispebjerg and Frederiksberg Hospital  Copenhagen Denmark"},{"name":"Gastro Unit Copenhagen University Hospital\u2014Amager and Hvidovre Hospital  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5018-5232","authenticated-orcid":false,"given":"Henriette","family":"Ytting","sequence":"additional","affiliation":[{"name":"Gastro Unit Copenhagen University Hospital\u2014Amager and Hvidovre Hospital  Hvidovre Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annelaura Bach","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Copenhagen University Hospital\u2014Bispebjerg and Frederiksberg Hospital  Copenhagen Denmark"},{"name":"Novo Nordisk Foundation Center for Protein Research Faculty of Health and Medical Sciences, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikkel Parsberg","family":"Werge","sequence":"additional","affiliation":[{"name":"Gastro Unit Copenhagen University Hospital\u2014Amager and Hvidovre Hospital  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias Badal","family":"Rashu","sequence":"additional","affiliation":[{"name":"Gastro Unit Copenhagen University Hospital\u2014Amager and Hvidovre Hospital  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8753-4096","authenticated-orcid":false,"given":"Liv Eline","family":"Hetland","sequence":"additional","affiliation":[{"name":"Gastro Unit Copenhagen University Hospital\u2014Amager and Hvidovre Hospital  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mira","family":"Thing","sequence":"additional","affiliation":[{"name":"Gastro Unit Copenhagen University Hospital\u2014Amager and Hvidovre Hospital  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puria","family":"Nabilou","sequence":"additional","affiliation":[{"name":"Gastro Unit Copenhagen University Hospital\u2014Amager and Hvidovre Hospital  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Burisch","sequence":"additional","affiliation":[{"name":"Gastro Unit Copenhagen University Hospital\u2014Amager and Hvidovre Hospital  Hvidovre Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders Ellek\u00e6r","family":"Junker","sequence":"additional","affiliation":[{"name":"Gastro Unit Copenhagen University Hospital\u2014Amager and Hvidovre Hospital  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise","family":"Hobolth","sequence":"additional","affiliation":[{"name":"Gastro Unit Copenhagen University Hospital\u2014Amager and Hvidovre Hospital  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Mortensen","sequence":"additional","affiliation":[{"name":"Gastro Unit Copenhagen University Hospital\u2014Amager and Hvidovre Hospital  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flemming","family":"Tofteng","sequence":"additional","affiliation":[{"name":"Gastro Unit Copenhagen University Hospital\u2014Amager and Hvidovre Hospital  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flemming","family":"Bendtsen","sequence":"additional","affiliation":[{"name":"Gastro Unit Copenhagen University Hospital\u2014Amager and Hvidovre Hospital  Hvidovre Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9684-7764","authenticated-orcid":false,"given":"S\u00f8ren","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences, University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Clinical Physiology and Nuclear Medicine Center for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital\u2014Amager and Hvidovre Hospital  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mogens","family":"Vyberg","sequence":"additional","affiliation":[{"name":"Department of Pathology Copenhagen University Hospital\u2014Amager and Hvidovre Hospital  Hvidovre Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza Rafiolsadat","family":"Serizawa","sequence":"additional","affiliation":[{"name":"Department of Pathology Copenhagen University Hospital\u2014Amager and Hvidovre Hospital  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Winther\u2010S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Copenhagen University Hospital\u2014Bispebjerg and Frederiksberg Hospital  Copenhagen Denmark"},{"name":"Novo Nordisk Foundation Center for Protein Research Faculty of Health and Medical Sciences, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper Sloth","family":"Kellemann","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Copenhagen University Hospital\u2014Bispebjerg and Frederiksberg Hospital  Copenhagen Denmark"},{"name":"Gastro Unit Copenhagen University Hospital\u2014Amager and Hvidovre Hospital  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9462-4468","authenticated-orcid":false,"given":"Lise Lotte","family":"Gluud","sequence":"additional","affiliation":[{"name":"Gastro Unit Copenhagen University Hospital\u2014Amager and Hvidovre Hospital  Hvidovre Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4230-5753","authenticated-orcid":false,"given":"Nicolai Jacob","family":"Wewer Albrechtsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Copenhagen University Hospital\u2014Bispebjerg and Frederiksberg Hospital  Copenhagen Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences, University of Copenhagen  Copenhagen Denmark"},{"name":"Novo Nordisk Foundation Center for Protein Research Faculty of Health and Medical Sciences, University of Copenhagen  Copenhagen Denmark"},{"name":"Copenhagen Center for Translational Research Copenhagen University Hospital\u2014Bispebjerg and Frederiksberg Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/HEP.31065"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.06.030"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001801"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JHEP.2014.06.030"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JHEP.2013.10.020"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/LIV.15217"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.32074\/1591\u2010951X\u2010241"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168\u20108278(99)80297\u20109"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22322"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00535\u2010010\u20100316\u20103"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/APT.17191"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2020.02.001"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.4018\/978-1-4666-3604-0.ch027"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2AN01246D"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/NATURE19949"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/MCP.M112.018713"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS24087479"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/PRCA.201700153"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS241512207"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS24020959"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001779"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010023\u201006592\u20106"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.5b00981"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1214\/16\u2010AOAS920"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.2c00473"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.06.003"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41423\u2010021\u201000768\u20108"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196\u20109781(03)00083\u20104"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/HEP.1840180408"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000013873"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1365\u20102249.1994.TB06019.X"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1530\u20100277.2006.00292.X"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACI.2009.09.046"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI12462"},{"issue":"8","key":"e_1_2_11_37_1","first-page":"1727","article-title":"VH4\u201034 Encoded Antibodies in Systemic Lupus Erythematosus: A Specific Diagnostic Marker That Correlates With Clinical Disease Characteristics","volume":"26","author":"Vollenhoven R. F.","year":"1999","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS19051308"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365517909106129"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JTAUTO.2019.100017"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1074\/JBC.M114.635763"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1136\/GUT.9.2.193"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/S12072\u2010015\u20109665\u20106"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0885\u20104505(88)90132\u20106"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2021.1930560"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.3748\/WJG.V25.I36.5451"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1365\u20102036.2007.03509.X"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JHEPR.2023.100712"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1136\/GUT.40.4.544"},{"issue":"80","key":"e_1_2_11_50_1","first-page":"2301","article-title":"Significance of Hyperglobulinemia in Severe Chronic Liver Diseases \u2010 With Special Reference to the Correlation Between Serum Globulin\/IgG Level and ICG Clearance","volume":"54","author":"Tanaka S.","year":"2007","journal-title":"Hepato\u2010Gastroenterology"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2014.934910"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.08.052"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23412"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/LIV.15728"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v113.pm9352873"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0925\u20104439(01)00045\u2010x"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1365\u20102265.2011.04291.X"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000002594"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15720"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00047.2024"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.3892\/IJMM_00000173\/HTML"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.3904\/KJIM.2018.214"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.3892\/IJMM.2012.1106"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009\u20108981(89)90216\u20107"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/HEP.22149"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/PMIC.200300757"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1021\/PR700861S"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BBRC.2007.12.075"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1196\/ANNALS.1398.041"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/CMI.2010.72"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMA.2024.0442"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PHARMTHERA.2019.01.006"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.3390\/JCM7090258"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1097\/HC9.0000000000000124"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.3390\/NU13114014"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.15252\/msb.20188793"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41591\u2010022\u201001850\u2010Y"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.15252\/msb.20156297"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ARR.2020.101070"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/PMIC.200900496"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1537\u20102995.2011.03316.X"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.70273","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T01:54:19Z","timestamp":1760406859000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.70273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,17]]},"references-count":80,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/apt.70273"],"URL":"https:\/\/doi.org\/10.1111\/apt.70273","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,17]]},"assertion":[{"value":"2025-03-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}