{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T22:23:28Z","timestamp":1780352608436,"version":"3.54.1"},"reference-count":10,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,7,27]],"date-time":"2025-07-27T00:00:00Z","timestamp":1753574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100031365","name":"Oslo universitetssykehus HF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005366","name":"Universitetet i Oslo","doi-asserted-by":"publisher","award":["WL\u2010IMMUNOLOGY"],"award-info":[{"award-number":["WL\u2010IMMUNOLOGY"]}],"id":[{"id":"10.13039\/501100005366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Coeliac disease is an autoimmune disorder driven by gluten and managed through a strict gluten\u2010free diet. We tested teriflunomide, a drug known for its ability to alter T\u2010cell activity, in a phase 2a trial of 15 patients with coeliac disease. Participants received teriflunomide or placebo including a loading dose, followed by a 3\u2010day oral gluten challenge to monitor T\u2010cell responses. The main aim was to observe attenuation of gluten\u2010specific T\u2010cell activation markers after gluten exposure. We found no significant differences in T\u2010cell activity between groups, concluding that teriflunomide is ineffective as a non\u2010dietary treatment for coeliac disease.<\/jats:p>","DOI":"10.1111\/apt.70301","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T05:44:28Z","timestamp":1753681468000},"page":"1027-1031","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Research Communication: Teriflunomide Does Not Affect Gluten\u2010Specific T\u2010Cell Activity in Coeliac Disease\u2014A Randomised, Placebo\u2010Controlled Trial"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2580-1678","authenticated-orcid":false,"given":"Louise F.","family":"Risnes","sequence":"first","affiliation":[{"name":"Norwegian Centre for Coeliac Disease Research University of Oslo  Oslo Norway"},{"name":"Department of Immunology Oslo University Hospital\u2013Rikshospitalet  Oslo Norway"},{"name":"Department of Transplantation Medicine Oslo University Hospital\u2010Rikshospitalet  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margit","family":"Brottveit","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Oslo University Hospital\u2013Ullev\u00e5l  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida","family":"Robertsen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jostein","family":"Ibsen","sequence":"additional","affiliation":[{"name":"Norwegian Centre for Coeliac Disease Research University of Oslo  Oslo Norway"},{"name":"Department of Transplantation Medicine Oslo University Hospital\u2010Rikshospitalet  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Aabakken","sequence":"additional","affiliation":[{"name":"Department of Transplantation Medicine Oslo University Hospital\u2010Rikshospitalet  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie K.","family":"Johannesen","sequence":"additional","affiliation":[{"name":"Norwegian Centre for Coeliac Disease Research University of Oslo  Oslo Norway"},{"name":"Department of Immunology Oslo University Hospital\u2013Rikshospitalet  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stine R.","family":"Lund","sequence":"additional","affiliation":[{"name":"Norwegian Centre for Coeliac Disease Research University of Oslo  Oslo Norway"},{"name":"Department of Transplantation Medicine Oslo University Hospital\u2010Rikshospitalet  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siv K. B.","family":"Furholm","sequence":"additional","affiliation":[{"name":"Department of Transplantation Medicine Oslo University Hospital\u2010Rikshospitalet  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siv E. H.","family":"Isaksen","sequence":"additional","affiliation":[{"name":"Department of Transplantation Medicine Oslo University Hospital\u2010Rikshospitalet  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"\u00c5sberg","sequence":"additional","affiliation":[{"name":"Department of Transplantation Medicine Oslo University Hospital\u2010Rikshospitalet  Oslo Norway"},{"name":"Department of Pharmacy University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludvig M.","family":"Sollid","sequence":"additional","affiliation":[{"name":"Norwegian Centre for Coeliac Disease Research University of Oslo  Oslo Norway"},{"name":"Department of Immunology Oslo University Hospital\u2013Rikshospitalet  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Knut E. A.","family":"Lundin","sequence":"additional","affiliation":[{"name":"Norwegian Centre for Coeliac Disease Research University of Oslo  Oslo Norway"},{"name":"Department of Transplantation Medicine Oslo University Hospital\u2010Rikshospitalet  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2024.03.042"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756285614546855"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aao5563"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2019.05.009"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI98819"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.10.040"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640619874183"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102017\u2010314461"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(17)30110\u20103"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2468\u20101253(23)00107\u20103"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.70301","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T21:09:49Z","timestamp":1761167389000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.70301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,27]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/apt.70301"],"URL":"https:\/\/doi.org\/10.1111\/apt.70301","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,27]]},"assertion":[{"value":"2025-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}