{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:24:24Z","timestamp":1790717064825,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"11-12","license":[{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Patients with primary sclerosing cholangitis (PSC) and concomitant inflammatory bowel disease (IBD) are at increased risk of colorectal cancer (CRC). However, the risk of CRC in patients with PSC without IBD remains uncertain. We aimed to evaluate the risk of CRC in patients with PSC without a history of IBD using a large national database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study using the TriNetX database to identify patients \u2265\u200918\u2009years with PSC. Patients were then divided into two groups, PSC with IBD (PSC\u2010IBD cohort) and PSC without IBD (PSC non\u2010IBD cohort), and were matched with patients without a history of PSC or IBD (non\u2010PSC\/non\u2010IBD group) by using 1:1 propensity score matching. The primary outcome was the risk of first diagnosis of CRC. With censoring applied, Kaplan\u2013Meier analysis with hazard ratios (HRs) and 95% CIs was used to compare time\u2010to\u2010event rates at daily time intervals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PSC patients without IBD were at increased risk of CRC compared to the non\u2010PSC\/IBD cohort (aHR\u2009=\u20092.91; 95% CI: 1.6\u20136.0). Patients with PSC and IBD exhibited a higher risk of CRC (aHR\u2009=\u20096.5; 95% CI: 3.78\u201311.2), especially among the UC cohort (aHR\u2009=\u20096.3; 95% CI: 3.2\u201312.4). Patients with PSC were at increased risk of various gastrointestinal malignancies (aHR\u2009=\u200910.5; 95% CI: 7.3\u201315;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), including hepatobiliary cancers, pancreatic cancer, and hepatocellular carcinoma.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Our findings provide real\u2010world evidence that PSC is an independent risk factor for colorectal cancer, even in the absence of concomitant IBD. These results support the need for further research to determine whether patients with isolated PSC may benefit from tailored CRC surveillance strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70303","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T09:37:42Z","timestamp":1753349862000},"page":"1212-1219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Primary Sclerosing Cholangitis in the Absence of Inflammatory Bowel Disease Increases the Risk of Colorectal Cancer: A Multi\u2010Centre Propensity Score Matched Analysis"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8776-2176","authenticated-orcid":false,"given":"Saqr","family":"Alsakarneh","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Razan","family":"Aburumman","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1784-212X","authenticated-orcid":false,"given":"Mohammad","family":"Bilal","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University of Colorado  Denver Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1571-5856","authenticated-orcid":false,"given":"Adam S.","family":"Faye","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology New York University  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana G.","family":"Hashash","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aasma","family":"Shaukat","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology New York University  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i6.1956"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.08.027"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01156.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000152"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.12.035"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-107029"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.14029"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32771"},{"key":"e_1_2_9_10_1","unstructured":"\u201cTriNetX \u201daccessed February 22 2024 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