{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:57:45Z","timestamp":1791021465429,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100022419","name":"National Institute for Health Research Southampton Biomedical Research Centre","doi-asserted-by":"publisher","award":["NIHR203319"],"award-info":[{"award-number":["NIHR203319"]}],"id":[{"id":"10.13039\/501100022419","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070588"],"award-info":[{"award-number":["82070588"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370577"],"award-info":[{"award-number":["82370577"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["823B2040"],"award-info":[{"award-number":["823B2040"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92359304"],"award-info":[{"award-number":["92359304"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFA1800801"],"award-info":[{"award-number":["2023YFA1800801"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Liver fibrosis may be associated with coronary artery disease (CAD) and adverse cardiovascular outcomes, but data remain limited. This study aimed to explore the relationship between liver fibrosis and the incidence of CAD, stent thrombosis (ST), in\u2010stent restenosis (ISR) and long\u2010term clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two cohorts were analysed: the UK Biobank (UKB) cohort examined liver fibrosis and CAD incidence and clinical outcomes in the general population, while the Wenzhou cohort assessed its relationship with ST and ISR and long\u2010term outcomes in post\u2010PCI patients. CAD incidence was defined as coronary stenosis \u2265\u200950% or clinical events, such as myocardial ischaemia, myocardial infarction and acute coronary syndrome. ST was confirmed via angiography, and ISR was defined as \u2265\u200950% stenosis within the stent. Major adverse cardiovascular events (MACE) included all\u2010cause mortality, myocardial infarction, heart failure and stroke. Liver fibrosis was assessed using FIB\u20104, categorised as \u2264\u20091.3, 1.3\u20132.67 and &gt;\u20092.67.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      394,625 participants were included. In the UKB cohort (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009380,638), 7102 (1.9%) had FIB\u20104\u2009&gt;\u20092.67. Over 14.4\u2009years, FIB\u20104\u2009&gt;\u20092.67 was associated with higher CAD incidence (aHR\u2009=\u20091.41,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and MACE (aHR\u2009=\u20091.69,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In the Wenzhou cohort (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200913,987), 3173 (22.7%) had FIB\u20104\u2009&gt;\u20092.67. Over 3.0\u2009years, FIB\u20104\u2009&gt;\u20092.67 was associated with increased risks of ST and ISR (aHR\u2009=\u20091.34,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and MACE (aHR\u2009=\u20091.97,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Liver fibrosis is common among patients with CAD and is associated with CAD incidence, stent thrombosis, restenosis and long\u2010term cardiovascular risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70306","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T06:36:27Z","timestamp":1754030187000},"page":"70-80","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Liver Fibrosis and the Risk of Coronary Artery Disease, Stent Thrombosis, Restenosis and Adverse Clinical Outcomes"],"prefix":"10.1111","volume":"63","author":[{"given":"Na","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Hepatology, MAFLD Research Center The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5630-8759","authenticated-orcid":false,"given":"Tie","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Hepatology, MAFLD Research Center The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyi","family":"Xia","sequence":"additional","affiliation":[{"name":"Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging &amp; Interventional Radiology (Southeast University) Department of Radiology, Zhongda Hospital, Medical School of Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010Yang","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Hepatology, MAFLD Research Center The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Shapiro","sequence":"additional","affiliation":[{"name":"Center for Prevention of Cardiovascular Disease, Section on Cardiovascular Medicine Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory Y. H.","family":"Lip","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool Liverpool John Moores University and Liverpool Heart &amp; Chest Hospital  Liverpool UK"},{"name":"Department of Clinical Medicine, Danish Center for Health Services Research Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Han","family":"Fanren","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, the Heart Center The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010You","family":"Lian","sequence":"additional","affiliation":[{"name":"Department of Hepatology, MAFLD Research Center The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen\u2010Xiao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Hepatology, MAFLD Research Center The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Xuan","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Hepatology, MAFLD Research Center The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4325-3900","authenticated-orcid":false,"given":"Giovanni","family":"Targher","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Verona  Verona Italy"},{"name":"Metabolic Diseases Research Unit IRCCS Sacro Cuore \u2013 Don Calabria Hospital  Negrar di Valpolicella Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Byrne","sequence":"additional","affiliation":[{"name":"Southampton National Institute for Health and Care Research Biomedical Research Centre, University Hospital Southampton, and University of Southampton, Southampton General Hospital  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Lv","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, the Heart Center The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5041-7865","authenticated-orcid":false,"given":"Shenghong","family":"Ju","sequence":"additional","affiliation":[{"name":"Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging &amp; 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