{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T14:38:56Z","timestamp":1781188736303,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The burden of invasive fungal diseases (IFDs) in patients with complicated alcoholic hepatitis (CAH)\u2014defined by \u2265\u20092 hepatic (ascites, jaundice, liver failure, encephalopathy) or extrahepatic (coagulopathy, shock, kidney or respiratory failure) dysfunctions within 30\u2009days\u2014remains poorly characterised.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To assess the burden of IFDs in CAH and compare it with bacterial pneumonia (BP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective nationwide cohort study of adult CAH patients in France (2012\u20132021). The primary exposure were IFDs. The primary outcome was 3\u2010month mortality or liver transplantation. Associations were assessed with adjusted odds ratios (aORs) in complete\u2010case and propensity score\u2013matched cohorts. A 6\u2010week landmark analysis and time\u2010dependent Cox models were used to evaluate time\u2010varying effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 11,434 CAH patients (median age 55\u2009years; 72% male), 2.2% and 15% developed IFDs and BP, respectively. Three\u2010month survival was 17.5% (95% CI: 13.0\u201323.0) in IFDs, 46.8% (44.3\u201349.3) in BP and 60.0% (59.4\u201361.4) in those without either (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). IFDs occurred in 44.3% of patients with BP, and BP increased IFD risk (aOR 2.93, 95% CI: 2.23\u20133.84). In matched analyses, IFDs were associated with a fourfold increase in mortality (aOR 4.58, 95% CI: 3.02\u20137.20), while BP showed a lower association (aOR 1.23, 95% CI: 1.06\u20131.43). IFDs were strong time\u2010dependent predictors of death.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IFDs affected 1 in 50 CAH patients and carried a disproportionate mortality risk, compared with BP. These findings support the implementation of targeted screening and early antifungal strategies in CAH management, as for BP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70328","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T04:25:52Z","timestamp":1756787152000},"page":"222-230","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Burden of Invasive Fungal Diseases in Patients With Alcohol\u2010Related Hepatitis and Organ Failure"],"prefix":"10.1111","volume":"63","author":[{"given":"Charlotte","family":"Mouliade","sequence":"first","affiliation":[{"name":"AP\u2010HP.Centre, Groupe Hospitalier Cochin Port Royal, DMU Canc\u00e9rologie et Sp\u00e9cialit\u00e9s M\u00e9dico\u2010Chirurgicales Service Des Maladies du Foie  Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Parlati","sequence":"additional","affiliation":[{"name":"AP\u2010HP.Centre, Groupe Hospitalier Cochin Port Royal, DMU Canc\u00e9rologie et Sp\u00e9cialit\u00e9s M\u00e9dico\u2010Chirurgicales Service Des Maladies du Foie  Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stylianos","family":"Tzedakis","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"AP\u2010HP.Centre, Groupe Hospitalier Cochin Port Royal, DMU Canc\u00e9rologie et Sp\u00e9cialit\u00e9s M\u00e9dico\u2010Chirurgicales Service de Chirurgie Digestive  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathis","family":"Collier","sequence":"additional","affiliation":[{"name":"AP\u2010HP.Centre, Groupe Hospitalier Cochin Port Royal, DMU Prime Unit\u00e9 de Recherche Clinique  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Bouam","sequence":"additional","affiliation":[{"name":"AP\u2010HP.Centre Universit\u00e9 de Paris, Groupe Hospitalier Cochin Port Royal, DMU PRIME Service D'information M\u00e9dicale  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Sogni","sequence":"additional","affiliation":[{"name":"AP\u2010HP.Centre, Groupe Hospitalier Cochin Port Royal, DMU Canc\u00e9rologie et Sp\u00e9cialit\u00e9s M\u00e9dico\u2010Chirurgicales Service Des Maladies du Foie  Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Lanternier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"AP\u2010HP, H\u00f4pital Universitaire Necker\u2010Enfants Malades, Universit\u00e9 de Paris, Service de Maladies 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