{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:52:13Z","timestamp":1792788733122,"version":"4.5.0"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20 GM130457"],"award-info":[{"award-number":["P20 GM130457"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Gastrointestinal bleeding (GIB) is a common medical emergency, with vitamin K antagonists (such as warfarin) and direct oral anticoagulants (DOACs) being important risk factors. We investigated the impact of anticoagulant medications on patient outcomes in upper and lower GIB. Using TriNetX, a global research database, we examined outcomes in patients with GIB with and without anticoagulant medications, propensity\u2010matched based on age, sex, race and co\u2010morbidities. Patients taking either DOACs or warfarin had more severe GIB and greater mortality than non\u2010anticoagulated patients, even after controlling for comorbid status. Anticoagulated patients also had higher rates of delayed endoscopy.<\/jats:p>","DOI":"10.1111\/apt.70329","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T05:58:46Z","timestamp":1755151126000},"page":"299-302","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Research Communication: The Risk and Outcomes of Gastrointestinal Bleeding in Patients Using Warfarin or Direct Oral Anticoagulants"],"prefix":"10.1111","volume":"63","author":[{"given":"Lauren","family":"Holtslander","sequence":"first","affiliation":[{"name":"Digestive Disease Research Center Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3751-2961","authenticated-orcid":false,"given":"Don C.","family":"Rockey","sequence":"additional","affiliation":[{"name":"Digestive Disease Research Center Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001245"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-017-4882-6"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.12.018"},{"issue":"10","key":"e_1_2_8_5_1","first-page":"599","article-title":"Severity of Gastrointestinal Bleeding Is Similar Between Patients Receiving Direct Oral Anticoagulants or Vitamin K Antagonists","volume":"114","author":"Alcal\u00e1\u2010Gonz\u00e1lez L. G.","year":"2022","journal-title":"Revista Espa\u00f1ola de Enfermedades Digestivas"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2016.07.007"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12485"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.003725"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl230406"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-024-07589-7"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.11.037"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.70329","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T10:32:58Z","timestamp":1767004378000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.70329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,13]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/apt.70329"],"URL":"https:\/\/doi.org\/10.1111\/apt.70329","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,13]]},"assertion":[{"value":"2025-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}