{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T02:26:53Z","timestamp":1792895213611,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009718","name":"Crohn's and Colitis Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009718","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008247","name":"University of Otago","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008247","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1190265"],"award-info":[{"award-number":["GNT1190265"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ingestible wireless motility capsules enable locoregional quantification of luminal pH and concentrations of hydrogen and carbon dioxide in the human colon.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate these measures in the colon of healthy adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Gas\u2010sensing and pH\u2010sensing wireless motility capsules were ingested tandemly and repeatedly over time. Measurements were analysed and compared in proximal and distal segments of the colon.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In paired datasets from 37 participants, colonic pH rose from a median 6.3 (IQR 5.8\u20136.9) proximally to 7.0 (6.6\u20137.2) distally (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Concentrations of carbon dioxide rose in nearly all participants from 12.7 (9.1\u201318.6) proximally to 18.8 (11.9\u201328.1) %.h\/h distally (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) with a positive correlation between proximal and distal colon (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.76;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Hydrogen concentrations showed widely varied proximal\u2010to\u2010distal gradients with an increase in 69% of participants, but no correlation between proximal and distal colon measures. No significant correlations between colonic pH, hydrogen concentrations, and carbon dioxide concentrations were observed. Comparison of hydrogen and carbon dioxide concentrations between tandem gas\u2010sensing capsules by Bland\u2013Altman analysis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200924) showed minimal (&lt;\u20091.2%) bias for both measures, and gas metrics on repeat ingestion were similar (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920). However, there was greater variance in the distal colon.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both wireless motility capsules evaluate different yet complementary aspects of colonic fermentation. Carbon dioxide concentrations that most likely reflect overall microbial metabolic activity were consistently greater distally, while proximal\u2010to\u2010distal gradients in hydrogen concentrations varied, likely due to inter\u2010subject variations in dietary carbohydrate and\/or methanogenesis. Luminal pH poorly reflects carbohydrate fermentation in the distal colon.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>ACTRN12619001219178 and ACTRN12622000422729<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70345","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T04:15:37Z","timestamp":1756268137000},"page":"242-253","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Telemetric Assessment and Comparison of Regional Colonic Metabolic Activity in Ambulant Healthy Individuals Using pH and Gas\u2010Sensing Wireless Motility Capsules"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5250-2086","authenticated-orcid":false,"given":"Phoebe A.","family":"Thwaites","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, School of Translational Medicine Monash University and Alfred Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5301-2457","authenticated-orcid":false,"given":"Chu K.","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, School of Translational Medicine Monash University and Alfred Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8768-8511","authenticated-orcid":false,"given":"Jasjot","family":"Maggo","sequence":"additional","affiliation":[{"name":"University of Otago  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2284-6288","authenticated-orcid":false,"given":"Francis 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