{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:15:27Z","timestamp":1785795327740,"version":"3.56.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Autoimmune hepatitis (AIH) may progress to advanced chronic liver disease (ACLD) with clinically significant portal hypertension (CSPH). In this study, we evaluated the prevalence of different clinical CSPH features and their prognostic impact regarding decompensation, liver transplantation (LTX) and death in patients with AIH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Patients with confirmed AIH diagnosis (sIAIHG\u2010Score \u2265\u20096) managed at the Vienna General Hospital between 2005 and 2023 were retrospectively analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 271 included patients (76.4% female) with AIH,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200960 (22.1%) presented clinical features of CSPH at diagnosis. During a median follow\u2010up of 7.2 (IQR 2.9\u201312.7) years, the proportion with CSPH features increased to\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009104 (38.4%). In a multivariable cox regression analysis, both compensated (aHR: 5.77, 95% CI: [1.47\u201322.71],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012) and decompensated features of CSPH (aHR: 15.73, 95% CI: [4.17\u201359.33],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) were associated with an increased risk of LTX\/death, whereas complete biochemical response and higher albumin levels were identified as protective factors. The BAVENO\u2010VII criteria for ruling\u2010out CSPH (liver stiffness &lt;\u200915\u2009kPa and platelet count \u2265\u2009150\u2009G\/L) identified AIH patients with a negligible 10Y cumulative incidence of hepatic decompensation (0.8%) and a favourable 10Y transplant\u2010free survival (97.8%). Overall,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200916 (5.9%) patients died, with\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910 deaths caused by CSPH\u2010related complications.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with AIH, clinical features of CSPH reflect the risk of future hepatic decompensation and mortality. Hence, regular screening for CSPH in AIH patients seems warranted to ensure timely initiation of adequate CSPH\u2010directed treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70349","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T14:05:31Z","timestamp":1756389931000},"page":"264-275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Features of Portal Hypertension and Their Prognostic Implications in Patients With Autoimmune Hepatitis"],"prefix":"10.1111","volume":"63","author":[{"given":"Lukas","family":"Burghart","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine III Medical University of Vienna  Vienna Austria"},{"name":"Klinik Ottakring, Wiener Gesundheitsverbund  Vienna 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