{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:38:10Z","timestamp":1790948290108,"version":"4.1.0"},"reference-count":65,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Primary sclerosing cholangitis (PSC) is a rare disease that paradoxically accounts for 5%\u201315% of liver transplants (LT). The paucity of liver donors is boosting living donor LT (LDLT). We reviewed the literature regarding outcomes of LT in PSC, comparing LDLT with deceased donor LT (DDLT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic review with meta\u2010analysis was performed through a search on: PubMed, Web\u2010of\u2010Science, Scopus and Cochrane Central, from inception to December 2024. In total, 22 studies were included, enrolling 22,024 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with LDLT, DDLT was associated with lower 1\u2010 (93.80% [95% CI 93.29\u201394.31] vs. 95.78% [95% CI 94.68\u201396.88]), 3\u2010 (88.81% [95% CI 88.14\u201389.48] vs. 93.23% [95% CI 91.85\u201394.61]) and 5\u2010year survival (85.18% [95% CI 84.43\u201385.92] vs. 91.54% [95% CI 91.01\u201393.07]), although it had no impact on graft survival. DDLT was associated with a higher risk of post\u2010LT sepsis (OR 3.68 [95% CI 1.02\u201313.26]), acute rejection (OR 1.75 [95% CI 1.12\u20132.73]) and PSC recurrence (OR 1.63 [95% CI 1.10\u20132.42]), but a lower risk of biliary complications (OR 0.29 [95% CI 0.11\u20130.78]). DDLT recipients were older (MD 4.26\u2009years [95% CI 2.42\u20136.10]), with higher metabolic dysfunction, more advanced liver disease (higher MELD: MD 6.63 [95% CI 5.56\u20137.70]), but lower chances of having inflammatory bowel disease (OR 0.66 [95% CI 0.50\u20130.87]) or cholangiocarcinoma (OR 0.70 [95% CI 0.53\u20130.92]). DDLT donors were older (MD 2.46\u2009years [95% CI 0.76\u20134.15]) and cold ischemia time was longer (MD 5.63\u2009h [95% CI 3.18\u20138.08]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In PSC, LDLT seems to be associated with higher post\u2010LT survival, compared with DDLT. This could be explained by earlier referral to LT with lower liver disease burden and better performance status; better graft quality; and shorter cold ischaemia time. PSC patients requiring LT should be encouraged to consider LDLT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.70357","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T04:26:42Z","timestamp":1756787202000},"page":"768-787","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Meta\u2010Analysis: Comparison of Living Versus Deceased Liver Transplantation for Primary Sclerosing Cholangitis"],"prefix":"10.1111","volume":"62","author":[{"given":"Ana Beatriz","family":"Afonso","sequence":"first","affiliation":[{"name":"Cl\u00ednica Universit\u00e1ria de Gastrenterologia, Faculdade de Medicina Universidade de Lisboa  Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Morais","family":"da Silva","sequence":"additional","affiliation":[{"name":"USF Gr\u00e3o Vasco, ULS Viseu D\u00e3o Laf\u00f5es  Viseu Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo","family":"Nogueira","sequence":"additional","affiliation":[{"name":"\u00c1rea Disciplinar Aut\u00f3noma de Bioestat\u00edstica (Laborat\u00f3rio de Biomatem\u00e1tica), Faculdade de Medicina Universidade de Lisboa  Lisboa Portugal"},{"name":"Laborat\u00f3rio Associado TERRA, Faculdade de Medicina, Instituto de Sa\u00fade Ambiental Universidade de Lisboa  Lisboa Portugal"},{"name":"Escola Superior de Enfermagem de Lisboa Centro de Investiga\u00e7\u00e3o, Inova\u00e7\u00e3o e Desenvolvimento em Enfermagem de Lisboa (CIDNUR)  Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7769-7860","authenticated-orcid":false,"given":"Mariana Verdelho","family":"Machado","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Universit\u00e1ria de Gastrenterologia, Faculdade de Medicina Universidade de Lisboa  Lisboa Portugal"},{"name":"Unidade de Oncologia Digestiva, Funda\u00e7\u00e3o Champalimaud  Lisboa Portugal"},{"name":"Servi\u00e7o de Gastrenterologia, Hospital de Vila Franca de Xira  Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.07.022"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izad276"},{"key":"e_1_2_9_4_1","first-page":"1097","article-title":"Medical Treatment of PSC: What Have We Learned and Where Are We Going?","volume":"10","author":"Karlsen T. 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