{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:14:43Z","timestamp":1760487283975,"version":"build-2065373602"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012276","name":"Tillotts Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012276","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>5\u2010Aminosalicylate (5\u2010ASA) is recommended for the treatment of mild\u2010to\u2010moderate ulcerative colitis (UC). However, adherence may be low; poor adherence is associated with an increased risk for flares.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate whether a regimen of a single 1600\u2009mg tablet of 5\u2010ASA improves adherence with preserved remission rates compared to a conventional regimen of three 800\u2009mg tablets.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 178 patients with UC (89 per group) in this open\u2010label randomised controlled phase IV trial. Patients had to have stable remission on 5\u2010ASA for at least 2 months and no concomitant diseases that could affect compliance. We randomised patients (1:1) to either receive Asacol 1600\u2009mg single tablet or Asacol 2400\u2009mg (three tablets of 800\u2009mg once daily) for 12\u2009months. Patients were assessed five times during the 12\u2009months, where medicine was delivered and received, blood and stool samples were collected and symptom scores were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010two patients taking a single tablet and 78 taking three tablets were adherent (<jats:italic>p<\/jats:italic>\u2009=\u20090.32). Fewer patients in the 1600\u2009mg group missed doses (24.5 vs. 26.5). There was no difference in the number of relapses or proportions experiencing relapse. Neither adherence nor treatment group was a significant predictor of relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The single\u2010tablet lower dose treatment could be a feasible alternative to the conventional three\u2010tablet regimen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p>The study was registered at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">Clinicaltrials.gov<\/jats:ext-link> (ID NCT04133194) and approved by The Danish Medicine Agency and The National Committee on Health Research Ethics (EudraCT 2019\u2010002070\u201031)<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.70375","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T09:00:45Z","timestamp":1758013245000},"page":"877-886","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Trial: Evaluating a Single 1600\u2009mg Tablet Regimen of 5\u2010Aminosalicylate for Ulcerative Colitis\u2014The <scp>EASI<\/scp> Trial"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1991-8295","authenticated-orcid":false,"given":"Rie Louise M\u00f8ller","family":"Nordestgaard","sequence":"first","affiliation":[{"name":"Gastrounit, Medical Division Copenhagen University Hospital\u2014Amager and Hvidovre  Hvidovre Denmark"},{"name":"Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University Hospital\u2014Amager and Hvidovre  Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bobby","family":"Lo","sequence":"additional","affiliation":[{"name":"Gastrounit, Medical Division Copenhagen University Hospital\u2014Amager and Hvidovre  Hvidovre Denmark"},{"name":"Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University 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