{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T12:30:41Z","timestamp":1790944241243,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Non\u2010invasive tests (NITs) are not currently approved as biomarkers of treatment response for patients with metabolic dysfunction\u2010associated steatohepatitis (MASH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This retrospective study explored a panel of NITs for assessing response to semaglutide treatment in patients with MASH randomised in a phase 2b trial (NCT02970942).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The present study was performed using the completer population (268 patients), defined as all patients who were randomised, remained on treatment throughout the trial, and had liver biopsy and NIT results at baseline and week 72. Semaglutide treatment arms were analysed as one semaglutide pooled group. Multiple NITs (alanine transaminase, aspartate transaminase [AST], controlled attenuation parameter, CK18\u2010M30\/M65, SomaSignal nonalcoholic steatohepatitis tests, FibroScan\u2010AST, NIS\u20104, metabolomics advanced steatohepatitis fibrosis score, fibrosis\u20104 index, liver stiffness measure [LSM], enhanced liver fibrosis [ELF], PRO\u2010C3 and ADAPT) were assessed. Treatment response was evaluated by NITs using either mean changes, responder groups, or risk categories from baseline to week 72.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Semaglutide treatment led to significant reductions versus placebo in all NIT scores from as early as 28\u2009weeks. More patients had MASH improvement and fewer had fibrosis progression versus placebo when assessed by a 20% NIT response (0.5\u2009U for ELF); among patients with baseline LSM &gt;\u20098\u2009kPa and ELF &gt;\u20099.8\u2009U, a larger proportion achieved LSM &lt;\u20098\u2009kPa and ELF &lt;\u20099.8\u2009kPa with semaglutide versus placebo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>NITs may be used for assessing a treatment response in patients with MASH. Further studies should confirm the treatment effect of NITs and evaluate the association of NIT changes to outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70376","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T09:50:46Z","timestamp":1758621046000},"page":"396-404","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Exploration of Multiple Non\u2010Invasive Tests for Assessing Response to Treatment in a Semaglutide Phase 2b Trial in Patients with\n                    <scp>MASH<\/scp>"],"prefix":"10.1111","volume":"63","author":[{"given":"Louise Maymann","family":"Nitze","sequence":"first","affiliation":[{"name":"Novo Nordisk A\/S, Development  S\u00f8borg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3051-0111","authenticated-orcid":false,"given":"Vlad","family":"Ratziu","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Institute for Cardiometabolism and Nutrition H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re, APHP, INSERM UMRS 1138 CRC  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8682-5748","authenticated-orcid":false,"given":"Arun J.","family":"Sanyal","sequence":"additional","affiliation":[{"name":"Stravitz\u2010Sanyal Institute for Liver Disease and Metabolic Health Virginia Commonwealth University School of Medicine  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent Wai\u2010Sun","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Balendran","sequence":"additional","affiliation":[{"name":"Novo Nordisk A\/S, Development  S\u00f8borg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Fleckner","sequence":"additional","affiliation":[{"name":"Novo Nordisk A\/S, Research &amp; 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