{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:58:21Z","timestamp":1781881101444,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["FRN 178435"],"award-info":[{"award-number":["FRN 178435"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010564","name":"Academic Medical Organization of Southwestern Ontario","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Paradoxical psoriasis (PP) is an adverse drug reaction associated with anti\u2010tumour necrosis factor (TNF)\u2010\u03b1 therapy leading to disfiguring skin lesions that may impact an individual's quality of life and affect their inflammatory bowel disease (IBD) care. To date, there are no tools to identify individuals at risk for PP. IL\u201023 receptor (IL23R) gene polymorphisms have been linked to psoriasis and may be implicated in PP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      To evaluate the association between the\n                      <jats:italic>IL23R1142G&gt;A<\/jats:italic>\n                      single nucleotide variant and the occurrence of PP in an anti\u2010TNF\u03b1\u2010treated IBD population and assess other clinical variables associated with PP development.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In a retrospective cohort study conducted in anti\u2010TNF\u03b1\u2010exposed adult patients with IBD, participants were screened for the\n                      <jats:italic>IL23R1142G&gt;A<\/jats:italic>\n                      variant genotype and the occurrence of PP was assessed. Participants were additionally assessed for clinical variables associated with PP development and for the impact of PP on IBD treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 499 patients, the incidence of PP was 5.1% (29\/570) with 570 unique anti\u2010TNF\u03b1 exposures. Most patients had severe PP (69.0%) and required treatment cessation (69.0%), which resulted in complete resolution of PP. An\n                      <jats:italic>IL23R1142G&gt;A<\/jats:italic>\n                      variant genotype was highly associated with PP development (46.2% vs. 5.1%, OR\u2009=\u200917.8, 95% CI 7.8\u201340.0;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). No other clinical variables were associated with the occurrence of PP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Variation in the\n                      <jats:italic>IL23R<\/jats:italic>\n                      gene may identify those at risk of anti\u2010TNF\u03b1\u2010induced PP, beyond clinical variables. Further validation of this finding may promote its utility as a clinically actionable tool for the safe delivery of IBD medical therapy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70377","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T06:17:24Z","timestamp":1758089844000},"page":"405-413","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>IL23<\/scp>\n                    Receptor Polymorphism Is a Predictor of Anti\u2010Tumour Necrosis Factor\u2010\u03b1\u2010Induced Paradoxical Psoriasis in Inflammatory Bowel Disease"],"prefix":"10.1111","volume":"63","author":[{"given":"Navneet","family":"Natt","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Gindi","sequence":"additional","affiliation":[{"name":"Department of Medicine Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gio R.","family":"Dela Cruz","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology and Toxicology, Department of Medicine Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry","family":"Ponich","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Gregor","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilesh","family":"Chande","sequence":"additional","affiliation":[{"name":"Southwestern Ontario Inflammatory Bowel Disease Clinic  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie D.","family":"Beaton","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"McIntosh","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sey","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Western University  London Ontario Canada"},{"name":"Department of Medicine Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reena","family":"Khanna","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8148-1632","authenticated-orcid":false,"given":"Richard B.","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology and Toxicology, Department of Medicine Western University  London Ontario Canada"},{"name":"Department of Physiology &amp; 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