{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:33:30Z","timestamp":1782927210319,"version":"3.54.5"},"reference-count":62,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012276","name":"Tillotts Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012276","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The United Kingdom (UK) has one of the highest worldwide opioid prescription rates per capita. International guidelines caution against the use of opioids for chronic non\u2010malignant pain, including irritable bowel syndrome (IBS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To study the prevalence and impact of regular opioid use among people with Rome IV IBS in community settings in the UK.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We collected demographic, quality of life (QoL), psychological symptoms, and healthcare utilisation data from 752 people with Rome IV IBS. Participants were recruited via electronic mailshot in July 2021 through ContactME\u2010IBS, a UK registry of persons diagnosed with IBS primarily by a general practitioner or gastroenterologist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among participants, 148 (19.7%) reported taking an opioid regularly. The prevalence of opioid use did not vary across IBS subtypes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.10). Disease\u2010specific and generic QoL were lower among opioid users than non\u2010users (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001, both analyses). Compared with non\u2010users, a greater proportion of opioid users had anxiety or depression (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001, both analyses) and greater overall activity impairment (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The direct healthcare costs related to investigations (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), IBS\u2010related medications (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and unplanned hospital attendances (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) were greater among participants who used opioids. Opioid users also expressed a greater willingness to accept the risk of death in return for a cure of IBS symptoms from a hypothetical medication (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Approximately one in five people with Rome IV IBS used opioids on a regular basis. Compared with non\u2010users, opioid users had worse QoL, greater psychological impairment, and higher direct healthcare costs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70400","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T21:16:39Z","timestamp":1759958199000},"page":"557-568","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prevalence of Opioid Use and Associated Healthcare Outcomes in Rome\n                    <scp>IV<\/scp>\n                    Irritable Bowel Syndrome in the United Kingdom"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0859-6470","authenticated-orcid":false,"given":"Mohsin F.","family":"Butt","sequence":"first","affiliation":[{"name":"NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham  Nottingham UK"},{"name":"Nottingham 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