{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T10:35:11Z","timestamp":1781346911433,"version":"3.54.1"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Small bowel (SB) capsule endoscopy (SBCE) is a key tool in patients with Crohn's disease (CD). Optimal bowel preparation remains debated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To compare the efficacy of a simplified preparation (clear liquid diet with 500\u2009mL of water pre\u2010 and 1\u2009L post\u2010capsule ingestion) to a polyethylene glycol (PEG)\u2010based preparation (24\u2009h\u2010residue\u2010free diet with 2\u2009L of PEG) in patients with established CD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this randomised, controlled, single\u2010blind, superiority, multicentre trial, patients were assigned 1:1 to either the simplified preparation or the PEG\u2010based preparation. Intestinal cleanliness (quantified by the KODA score and qualitatively evaluated), patient acceptability, diagnostic yield, capsule completion rate, and SB transit time (SBTT) were compared between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>With 142 SBCE, we observed no difference in intestinal cleanliness. Patients' acceptability of preparation and SBCE procedure was significantly higher with the simplified preparation. Diagnostic yield was similar, as well as the capsule completion rate and SBTT. The area under the receiver operating characteristic curve of the KODA score was 0.87 (95% CI: 0.84\u20130.90). Using a threshold of 2.25, the score allowed us to discriminate images with \u2018good\u2019 and \u2018fair or poor\u2019 cleanliness with accuracy, sensitivity, and specificity of 80%, 76%, and 84%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A simplified preparation consisting of a clear liquid diet and water is a viable alternative to a PEG\u2010based preparation prior to SBCE in patients with CD, offering comparable SB cleanliness and diagnostic outcomes while improving acceptability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier: NCT05117996 and the article was written in line with the Consolidated Standards of Reporting Trials (CONSORT) checklist\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70417","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T05:01:01Z","timestamp":1761022861000},"page":"57-69","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical Trial: Simplified Bowel Preparation for Small Bowel Capsule Endoscopy in Crohn's Disease"],"prefix":"10.1111","volume":"63","author":[{"given":"Rapha\u00eblle","family":"Rouveyre","sequence":"first","affiliation":[{"name":"Institut des Maladies de L'appareil Digestif (IMAD), H\u00e9pato\u2010Gastro\u2010Ent\u00e9rologie et Assistance Nutritionnelle, Inserm CIC 1413 Nantes Universit\u00e9, CHU Nantes  Nantes 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