{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T09:19:38Z","timestamp":1786439978206,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK13593701A1"],"award-info":[{"award-number":["R01DK13593701A1"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Advanced therapies increase the risk of shingles in inflammatory bowel diseases (IBD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To compare the risk of shingles with different advanced therapies in patients with IBD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We identified patients with IBD who initiated treatment with tumour necrosis factor (TNF) antagonists, anti\u2010integrins, anti\u2010interleukins, Janus kinase (JAK) inhibitors, or sphingosine\u20101 phosphate receptor (S1PR) modulators between 2016 and 2022 and had follow\u2010up for at least 1 year before and after treatment initiation. We estimated the incidence rate (IR per 100 person\u2010year [PY]) of shingles (overall and complicated) and compared the risk with different advanced therapies through multinomial propensity score\u2010based inverse probability of treatment weighting (IPTW), with propensity scores estimated through generalised boosted models, accounting for disease characteristics, healthcare utilisation, comorbidities and prior and concomitant medications. Weighted Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for multiple treatment comparisons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 21,675 patients followed over 27\u2009months. IRs per 100 PY of shingles and complicated shingles were: TNF antagonists 1.0\/0.3, anti\u2010integrin agents 1.4\/0.4, anti\u2010interleukins 1.2\/0.5, JAK inhibitors 3.3\/0.9 and S1PR modulators 2.0\/1.0. After adjusting for confounding variables, JAK inhibitors were associated with higher risks of shingles than TNF antagonists (HR 2.19; 1.28\u20133.75), anti\u2010integrins (HR 1.87; 1.12\u20133.14) and anti\u2010interleukins (HR 1.70; 0.98\u20132.96).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>JAK inhibitors were associated with 1.7\u20132.2\u2010fold higher risk of shingles than other advanced therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70418","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T06:51:01Z","timestamp":1760597461000},"page":"686-695","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Overall and Comparative Risk of Shingles With Advanced Therapies in Patients With Inflammatory Bowel Diseases"],"prefix":"10.1111","volume":"63","author":[{"given":"Dhruv","family":"Ahuja","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine University of California san Diego  La Jolla California USA"},{"name":"Department of Medicine Indira Gandhi Hospital  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo\u2010Kyung","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine University of California san Diego  La Jolla California USA"},{"name":"Division of Gastroenterology, Department of Internal Medicine Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan\u2010Hung","family":"Yeh","sequence":"additional","affiliation":[{"name":"Division of Biomedical Informatics, Department of Medicine University of California san Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagar B.","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine University of California san Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane W.","family":"Goodwin","sequence":"additional","affiliation":[{"name":"London Health Sciences Centre Research Institute  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4698-9948","authenticated-orcid":false,"given":"Christopher","family":"Ma","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Department of Community Health Sciences University of Calgary  Calgary Alberta 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