{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:13:10Z","timestamp":1791245590419,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007567","name":"City University of Hong Kong","doi-asserted-by":"publisher","award":["7020093"],"award-info":[{"award-number":["7020093"]}],"id":[{"id":"10.13039\/100007567","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>East Asia Pacific (EAP) faces a high burden of chronic liver disease (CLD), with metabolic dysfunction\u2010associated steatotic liver disease (MASLD) projected to account for about 80% of CLD prevalence by 2040. Using Global Burden of Disease 2021 data, we assessed CLD trends, transitions to hepatocellular carcinoma (HCC), and the cost\u2010effectiveness of non\u2010cirrhotic HCC surveillance. Despite declining viral hepatitis burden, MASLD and alcohol\u2010related CLD have risen. HCC surveillance in non\u2010cirrhotic patients was cost\u2010effective only for chronic hepatitis B in selected older age groups, with substantial variability across countries. These findings support refining surveillance guidelines and adaptation of risk stratification tools.<\/jats:p>","DOI":"10.1111\/apt.70428","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T05:55:34Z","timestamp":1761112534000},"page":"569-573","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Research Communication: Changing Aetiology of Chronic Liver Diseases in East Asia Pacific and\n                    <scp>HCC<\/scp>\n                    Surveillance in Non\u2010Cirrhotic Patients"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6531-2879","authenticated-orcid":false,"given":"Ming","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Public Health Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Liver Disease Center of Integrated Traditional Chinese and Western Medicine, Department of Radiology, Zhongda Hospital, Medical School Southeast University, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging &amp; Interventional Radiology (Southeast University)  Nanjing China"},{"name":"Basic Medicine Research and Innovation Center of Ministry of Education, Zhongda Hospital, Southeast University; State Key Laboratory of Digital Medical Engineering  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsz Ngai","family":"Mok","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Public Health Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3559-5855","authenticated-orcid":false,"given":"Xiaolong","family":"Qi","sequence":"additional","affiliation":[{"name":"Liver Disease Center of Integrated Traditional Chinese and Western Medicine, Department of Radiology, Zhongda Hospital, Medical School Southeast University, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging &amp; Interventional Radiology (Southeast University)  Nanjing China"},{"name":"Basic Medicine Research and Innovation Center of Ministry of Education, Zhongda Hospital, Southeast University; State Key Laboratory of Digital Medical Engineering  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8846-7515","authenticated-orcid":false,"given":"Wai\u2010kit","family":"Ming","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Public Health Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong  Hong Kong China"},{"name":"Institute of Global Governance and Innovation for a Shared Future, City University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-024-00967-4"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-018-0055-0"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.08.025"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2017.08.030"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-023-00818-8"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-020-10113-2"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29913"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/hep.0000000000000466"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000323"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002361"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.70428","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apt.70428","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.70428","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T19:28:55Z","timestamp":1771010935000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.70428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,21]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/apt.70428"],"URL":"https:\/\/doi.org\/10.1111\/apt.70428","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,21]]},"assertion":[{"value":"2025-05-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}