{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T05:35:26Z","timestamp":1771047326707,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There are limited data on colorectal cancer (CRC) risk after high\u2010grade dysplasia in inflammatory bowel disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To determine the long\u2010term CRC and neoplasia risk after a first diagnosis of high\u2010grade dysplasia in inflammatory bowel disease, and to assess utilisation of high\u2010grade dysplasia treatment strategies over the past three decades.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this nationwide retrospective cohort study, patients with colonic inflammatory bowel disease and high\u2010grade dysplasia diagnosis between 1991 and 2021 were extracted from the Dutch nationwide pathology databank (PALGA). The primary outcome was the cumulative incidence of metachronous CRC. Kaplan\u2013Meier curves were used to show proctocolectomy\u2010free survival per decade.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CRC was diagnosed in 348 of 1220 patients (28.5%). Of these, 204 (16.7%) were diagnosed with CRC within 6\u2009months after the first high\u2010grade dysplasia diagnosis and were considered synchronous patients. Metachronous CRC was diagnosed in 144 of 1016 patients (14.2%) after a median of 3.6\u2009years. The 1\u2010, 5\u2010 and 10\u2010year cumulative incidences of metachronous CRC after high\u2010grade dysplasia were 2.9%, 9.9% and 15.5%, respectively. The 1\u2010, 5\u2010 and 10\u2010year cumulative incidences of metachronous neoplasia were 18.3%, 51.2% and 68.0%, respectively. Proctocolectomy\u2010free survival after high\u2010grade dysplasia decreased over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The risk of synchronous and metachronous CRC after a diagnosis of high\u2010grade dysplasia underlines the high\u2010risk profile of this subgroup of patients with inflammatory bowel disease. The possible advantages of colon\u2010sparing treatment should be balanced with the higher risk of metachronous CRC and the subsequent need for stringent endoscopic surveillance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70429","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T07:20:36Z","timestamp":1761290436000},"page":"706-714","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["High Risk of Colorectal Cancer After High\u2010Grade Dysplasia in Inflammatory Bowel Disease Patients"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4247-3987","authenticated-orcid":false,"given":"Monica E. 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