{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:15:55Z","timestamp":1791825355815,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2306900"],"award-info":[{"award-number":["2023YFC2306900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Recent studies show that patients with hepatitis B virus (HBV)\u2010related decompensated cirrhosis who achieve recompensation can still experience further decompensation, suggesting that recompensation status can change over time. This study aimed to classify patterns of recompensation and charaterize the\u00a0clinical differences among these subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eligible patients with HBV\u2010related decompensated cirrhosis were enrolled from two cohorts. Clinical characteristics and complications were assessed every 6\u2009months for up to 5\u2009years following their first episode of decompensation. Recompensation was defined according to the Baveno VII criteria and further categorised as stable (no subsequent decompensation) or unstable (recurrent decompensation or recompensation following multiple decompensation episodes).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 378 patients were included; 294 (77.8%) achieved recompensation, while 84 (22.2%) did not. After a median follow\u2010up of 5.3\u2009years (IQR 4.4\u20135.8), recompensated patients were classified into stable recompensation (202\/378, 53.4%) and unstable recompensation (92\/378, 24.3%). The 5\u2009year rate of hepatocellular carcinoma (HCC) or all\u2010cause mortality was higher in the unstable group than the stable group (14.7% vs. 10.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.038), yet remained lower than in patients with ongoing decompensation. Liver function improvement was intermediate in the unstable group compared with the stable recompensation and ongoing decompensation. Logistic regression yielded the highest accuracy for predicting recompensation (AUROC\u2009=\u20090.884), while support vector machine algorithms best predicted stable recompensation (AUROC\u2009=\u20090.911).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Recompensation is not a uniform condition and should be further subclassified. Unstable recompensation is a distinct state with poorer survival than stable recompensation, yet better outcomes than ongoing decompensation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70430","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T15:39:59Z","timestamp":1761665999000},"page":"715-727","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Unstable Recompensation: An Intermediate Subtype in Patients With\n                    <scp>HBV<\/scp>\n                    \u2010Related Decompensated Cirrhosis"],"prefix":"10.1111","volume":"63","author":[{"given":"Shuai","family":"Xia","sequence":"first","affiliation":[{"name":"Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, State Key Lab of Digestive Health, National Clinical Research Center for Digestive Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiying","family":"He","sequence":"additional","affiliation":[{"name":"Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, State Key Lab of Digestive Health, National Clinical Research Center for Digestive Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5416-712X","authenticated-orcid":false,"given":"Xiaoning","family":"Wu","sequence":"additional","affiliation":[{"name":"Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, State Key Lab of Digestive Health, National Clinical Research Center for Digestive Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongjie","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine of Liver Disease Beijing YouAn Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8711-1579","authenticated-orcid":false,"given":"Chunqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Provincial Hospital Affiliated to Shandong First Medical University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqin","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The First Hospital of Shanxi Medical University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfeng","family":"Yang","sequence":"additional","affiliation":[{"name":"Liver Disease Department The Second Hospital of Nanjing, Affiliated to Medical School of South East University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Liver and Infectious Diseases Xiangya Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Rao","sequence":"additional","affiliation":[{"name":"Division of Hepatology, Liver Disease Center the Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqian","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and EBM Unit Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Diseases  Beijing 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