{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:44:20Z","timestamp":1787773460549,"version":"build-2784847793"},"reference-count":57,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Poor psychological health affects many patients with inflammatory bowel disease (IBD), but the persistence of these symptoms is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a longitudinal follow\u2010up study of patients whose anxiety and depression trajectories were established by symptom data collected at 3\u2010monthly intervals over the course of 1\u2009year. We collected further anxiety and depression symptom data at yearly intervals over 2\u2009years to determine the persistence of these symptoms in patients with IBD. Disease outcomes (flare\/need for glucocorticosteroids, escalation of medical therapy, hospitalisation, or intestinal resection) were recorded to determine the effect of mood trajectories on the natural history of IBD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 770 patients with established anxiety trajectories, 486 (63.1%) provided further anxiety symptom data at 12\u2009months, and 358 (45.5%) at 24\u2009months. Of the 777 patients with established depression trajectories, 491 (63.2%) provided further depression symptom data at 12\u2009months, and 362 (45.6%) at 24\u2009months. Participants with symptoms of anxiety at 24\u2009months were more likely to have a fluctuating, or persistently abnormal or worsening, anxiety trajectory during the first year (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 for trend). Participants with symptoms of depression at 24\u2009months were more likely to have a fluctuating, or persistently abnormal or worsening, depression trajectory during the first year (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 for trend). Adverse disease outcomes were no more likely according to anxiety or depression trajectories.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Poor psychological health persists for a substantial number of patients with IBD. Further work is needed to establish the long\u2010term effect of mood trajectories on disease outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70431","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T18:18:02Z","timestamp":1761070682000},"page":"811-820","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Persistence of Symptoms of Anxiety and Depression in Inflammatory Bowel Disease: A Longitudinal Follow\u2010Up Study"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6927-9498","authenticated-orcid":false,"given":"Christy","family":"Riggott","sequence":"first","affiliation":[{"name":"Leeds Gastroenterology Institute St. James's University Hospital  Leeds UK"},{"name":"Leeds Institute of Medical Research at St. James's University of Leeds  Leeds 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