{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:24:11Z","timestamp":1791397451836,"version":"4.3.3"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Alcohol\u2010associated liver disease (ALD) is a rapidly rising indication for liver transplantation. Early studies showed comparable post\u2010transplant outcomes but emerging data suggest long\u2010term survival benefits in ALD, thus warranting an analysis of waitlist and post\u2010transplant outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medline and Embase were searched from inception to 16 May 2025. Kaplan\u2013Meier curves were extracted to reconstruct individual participant data for pooled survival analysis of time\u2010to\u2010event outcomes using a random effects model. Cox regression\u2010generated hazard ratios (HRs) for survival outcomes, and odds ratios (ORs) for post\u2010transplant complications were obtained using pairwise meta\u2010analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      50 articles (382,614 patients) were included in the meta\u2010analysis. 6\u2010month, 1\u2010 and 2\u2010year waitlist survival in ALD patients was 79.7%, 72.7% and 63.8%, compared to 81.7%, 72.9% and 61.3% in non\u2010ALD patients. 1\u2010, 3\u2010, 5\u2010 and 10\u2010year post transplant patient survival was 91.3%, 83.0%, 76.1% and 60.2% in ALD, and 90.3%, 82.8%, 76.9% and 66.4% in non\u2010ALD. Waitlist (HR: 1.021, 95% CI: 0.519\u20132.009,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.95) and post\u2010transplant survivals (HR: 0.914, 95% CI: 0.805\u20131.039,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.17) were comparable between ALD and non\u2010ALD patients. ALD patients had a higher risk of de novo malignancy post\u2010transplant (OR: 2.194, 95% CI: 1.534\u20133.139,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this reconstructed individual patient data meta\u2010analysis, waitlist survival was comparable between ALD and non\u2010ALD patients. While early post\u2010transplant patient survival was similar, long\u2010term survival remained inferior in ALD, partly attributed to increased de novo malignancy. These findings highlight the need for improved candidate selection, addiction care, and cancer surveillance to maximise long\u2010term outcomes in the growing ALD transplant population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70434","type":"journal-article","created":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T04:50:36Z","timestamp":1761972636000},"page":"330-340","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Waitlist and Post\u2010Transplant Outcomes in Liver Transplantation for Alcohol\u2010Associated Liver Disease: An Individual Patient Data Meta\u2010Analysis"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5531-0175","authenticated-orcid":false,"given":"Glenn Jun Kit","family":"Ho","sequence":"first","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirudhula","family":"Gnanavelou","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan Yanzhe","family":"Lim","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Yang Yuxu","family":"Yeo","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine National University Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Nah","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine National University Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryant","family":"Low","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talia Yi Hui","family":"Chan","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanawin","family":"Pramotedham","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine National University Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi Yan","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine National University Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caleb Wei Hao","family":"Ng","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery National University Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine Kurume University School of Medicine  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Hepatology, Graduate School of Medicine Osaka Metropolitan University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Division of Metabolism and Endocrinology, Faculty of Medicine Saga University  Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0157-6066","authenticated-orcid":false,"given":"Vincent L.","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine University of Michigan Medical School  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazen","family":"Noureddin","sequence":"additional","affiliation":[{"name":"Houston Methodist Hospital and Houston Research Institute  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9724-4743","authenticated-orcid":false,"given":"Mark","family":"Muthiah","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore  Singapore Singapore"},{"name":"Division of Gastroenterology and Hepatology, Department of Medicine National University Hospital  Singapore Singapore"},{"name":"National University Centre for Organ Transplantation, National University Health System  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen Hui","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Medicine National University Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Shadab","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"University of Virginia School of Medicine  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3757-4986","authenticated-orcid":false,"given":"Eunice Xiang\u2010Xuan","family":"Tan","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore  Singapore Singapore"},{"name":"Division of Gastroenterology and Hepatology, Department of Medicine National University Hospital  Singapore Singapore"},{"name":"National University Centre for Organ Transplantation, National University Health System  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,31]]},"reference":[{"key":"e_1_2_13_2_1","volume-title":"StatPearls","author":"Patel R.","year":"2025"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14126"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2023.03.026"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32067"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.4065\/76.10.1021"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.10.033"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2024.04.025"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2022.06.013"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2017.469"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102288\u201012\u20109"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(18)31644\u20101"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.11.014"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2021.11.012"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.19407"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.06.032"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.6111"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3602"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39057.406644.68"},{"key":"e_1_2_13_23_1","unstructured":"G.Wells B.Shea D.O'Connell et\u00a0al. \u201cThe Newcastle\u2013Ottawa Scale (NOS) for Assessing the Quality of Non\u2010Randomized Studies in Meta\u2010Analysis \u201d(2021) https:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp."},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.09.033"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2025.01.022"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2018.6536"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/lvt.0000000000000394"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010018\u20100014\u20107"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20503"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.11.033"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.21037\/tgh.2019.11.18"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u20100012.2006.00527.x"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/mot.0000000000000507"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.08.004"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.70434","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apt.70434","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.70434","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T18:19:53Z","timestamp":1769797193000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.70434"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,31]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/apt.70434"],"URL":"https:\/\/doi.org\/10.1111\/apt.70434","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,31]]},"assertion":[{"value":"2025-08-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}