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This is a study of a cohort of adults with PBC who were started on seladelpar as second\u2010line therapy between October 2024 and March 2025. Of the 18 patients, 11 were trialed on a second\u2010line therapy prior to switching to seladelpar, whereas 7 of the patients started seladelpar as initial second\u2010line therapy. Biochemical response was achieved in 56.3% of patients and normalisation of alkaline phosphatase levels in 31.3% of patients after 1\u2009month of treatment. This study demonstrates the efficacy of seladelpar as a second\u2010line agent in a real\u2010world clinical setting.<\/jats:p>","DOI":"10.1111\/apt.70435","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:50:51Z","timestamp":1761807051000},"page":"728-731","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Research Communication: Real\u2010World Clinical Experience With Seladelpar in Primary Biliary Cholangitis"],"prefix":"10.1111","volume":"63","author":[{"given":"Selena Z.","family":"Kuo","sequence":"first","affiliation":[{"name":"NAFLD Research Center, Division of Gastroenterology University of California at San Diego  La Jolla California USA"},{"name":"Division of Gastroenterology University of California at San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5125-8031","authenticated-orcid":false,"given":"Jeffrey","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of California at San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Loomba","sequence":"additional","affiliation":[{"name":"NAFLD Research Center, Division of Gastroenterology University of California at San Diego  La Jolla California USA"},{"name":"Division of Gastroenterology University of California at San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/hep.0000000000001166"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30145"},{"key":"e_1_2_9_4_1","unstructured":"Drug Safety Communication \u201cSerious Liver Injury Being Observed in Patients Without Cirrhosis Taking Ocaliva (Obeticholic Acid) to Treat Primary Biliary Cholangitis \u201dFDA https:\/\/www.fda.gov\/drugs\/drug\u2010safety\u2010and\u2010availability\/serious\u2010liver\u2010injury\u2010being\u2010observed\u2010patients\u2010without\u2010cirrhosis\u2010taking\u2010ocaliva\u2010obeticholic\u2010acid\u2010treat."},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2312100"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.17755"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.70435","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apt.70435","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.70435","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T16:05:17Z","timestamp":1770998717000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.70435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,29]]},"references-count":5,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/apt.70435"],"URL":"https:\/\/doi.org\/10.1111\/apt.70435","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,29]]},"assertion":[{"value":"2025-05-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}