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We modelled age\u2010sex\u2010standardised annual cancer incidence (per 100,000 person\u2010years) over time by first\u2010order linear autoregression, and standardised cancer incidence and mortality rate ratios (SIR, SMR) by quasi\u2010Poisson regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The average annual percentage change (AAPC) in ED cancer incidence was stable among 110,919 people with IBD (0.108%\/year; 95% CI, \u22120.380, 0.599) but declined among 1,109,190 matched controls (\u22121.39%\/year; 95% CI, \u22121.57, \u22121.21). Among those with IBD, AAPC was significant for non\u2010Hodgkin's lymphoma (1.48%\/year; 95% CI, 0.161, 2.82), melanoma (1.77%\/year; 95% CI, 0.781, 2.77), cervical (2.31%\/year; 95% CI, 0.602, 4.10), uterine (4.41%\/year; 95% CI, 0.045, 8.96) and thyroid (8.10%\/year; 95% CI, 4.31, 12.0) cancers, and statistically greater than controls for cervical, ovarian, lung, and bladder cancers. During 2010\u20132020, ED cancer incidence was higher in those with IBD (SIR 1.20; 95% CI 1.15, 1.26), while ED cancer\u2010related mortality was specifically higher in those with Crohn's disease (CD; SMR 1.31; 95% CI 1.14, 1.51), as compared to matched controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ED cancer incidence has not changed among those with IBD but has declined among matched controls. Beyond 2010, ED cancer incidence is higher among those with IBD and cancer\u2010related mortality is higher among those with CD, relative to matched controls.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.70439","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T08:44:09Z","timestamp":1762850649000},"page":"859-873","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A Population\u2010Based Matched Cohort Study of Extra\u2010Digestive Cancer Incidence and Mortality in Individuals With and Without Inflammatory Bowel Disease"],"prefix":"10.1111","volume":"63","author":[{"given":"Sanjay K.","family":"Murthy","sequence":"first","affiliation":[{"name":"Department of Medicine and School of Epidemiology and Public Health University of Ottawa  Ottawa Ontario Canada"},{"name":"The Ottawa Hospital IBD Centre  Ottawa Ontario Canada"},{"name":"Ottawa Hospital Research Institute Clinical Epidemiology Program  Ottawa Ontario Canada"},{"name":"ICES  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faria","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Ottawa Hospital Research Institute Clinical Epidemiology Program  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Pugliese","sequence":"additional","affiliation":[{"name":"ICES  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Taljaard","sequence":"additional","affiliation":[{"name":"Ottawa Hospital Research Institute Clinical Epidemiology Program  Ottawa Ontario Canada"},{"name":"ICES  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parul","family":"Tandon","sequence":"additional","affiliation":[{"name":"ICES  Toronto Ontario Canada"},{"name":"Division of Gastroenterology and Hepatology, University Health Network University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla","family":"Matthews","sequence":"additional","affiliation":[{"name":"Department of Medicine Queens University  Kingston Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2719-0556","authenticated-orcid":false,"given":"Gilaad G.","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine and Community Health Sciences, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Coward","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine and Community Health Sciences, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8041-3574","authenticated-orcid":false,"given":"Charles N.","family":"Bernstein","sequence":"additional","affiliation":[{"name":"University of Manitoba IBD Clinical and Research Centre  Winnipeg Manitoba Canada"},{"name":"Department of Internal Medicine and Community Health Sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8855-3598","authenticated-orcid":false,"given":"Eric I.","family":"Benchimol","sequence":"additional","affiliation":[{"name":"ICES  Toronto Ontario Canada"},{"name":"SickKids Inflammatory Bowel Disease Centre, Division of Gastroenterology, Hepatology and Nutrition The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Department of Paediatrics and Institute of Health Policy, Management and Evaluation University of Toronto  Toronto Canada"},{"name":"Child Health Evaluative Sciences, SickKids Research Institute The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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