{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:44Z","timestamp":1787013884142,"version":"build-2736575974"},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK13593701A1"],"award-info":[{"award-number":["R01DK13593701A1"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We conducted a USA claims\u2010based cohort study in 20,705 patients with inflammatory bowel diseases (IBD) on advanced therapies to estimate the overall and comparative risk of tuberculosis between advanced therapies using inverse probability of treatment weighted Cox proportional hazards model. The incidence rate (IR, per 100,000 person\u2010years) of tuberculosis with TNF antagonists (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20099378) and non\u2010TNF\u2010targeting biologics (anti\u2010integrins [\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20095877], anti\u2010interleukins [\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20095450]) was similar (38 [95% CI, 8\u201369] vs. 33[7\u201359]). Adjusting for covariates, risk of tuberculosis was similar (HR, 1.16 [0.41\u20133.31]). In low incidence regions like USA, the incidence of tuberculosis after starting advanced therapies for IBD is very low, and comparable across advanced therapies.\n                  <\/jats:p>","DOI":"10.1111\/apt.70443","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T10:53:42Z","timestamp":1761735222000},"page":"885-887","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Research Communication: Risk of Tuberculosis With Advanced Therapies in 20,705 Patients With Inflammatory Bowel Diseases in Low Incidence Regions\u2014A U.S. Claims\u2010Based Study"],"prefix":"10.1111","volume":"63","author":[{"given":"Dhruv","family":"Ahuja","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine University of California San Diego  La Jolla California USA"},{"name":"Department of Medicine Indira Gandhi Hospital  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan\u2010Hung","family":"Yeh","sequence":"additional","affiliation":[{"name":"Division of Biomedical Informatics, Department of Medicine University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagar B.","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo\u2010kyung","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine University of California San Diego  La Jolla California USA"},{"name":"Division of Gastroenterology, Department of Medicine Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronghui","family":"Xu","sequence":"additional","affiliation":[{"name":"Biostatistics and Bioinformatics, Herbert Wertheim School of Public Health University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2640-7269","authenticated-orcid":false,"given":"Siddharth","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Mayo Clinic\u2014Arizona  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16952"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00655-2019"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000527"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.2049"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1989.10478873"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200690"},{"key":"e_1_2_8_8_1","doi-asserted-by":"crossref","DOI":"10.1177\/17562848241265013","article-title":"Comparative Risk of Serious Infections and Tuberculosis in Korean Patients With Inflammatory Bowel Disease Treated With Non\u2010Anti\u2010TNF Biologics or Anti\u2010TNF\u2010Alpha Agents: A Nationwide Population\u2010Based Cohort Study","volume":"17","author":"Kim M. J.","year":"2024","journal-title":"Therapeutic Advances in Gastroenterology"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2024.00076"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-311079"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjae013"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.70443","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/apt.70443","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.70443","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:24:19Z","timestamp":1773005059000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.70443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,29]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/apt.70443"],"URL":"https:\/\/doi.org\/10.1111\/apt.70443","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,29]]},"assertion":[{"value":"2025-07-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}